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Clinical data, survival, and prognosis of 426 cases of oropharyngeal cancer: a retrospective analysis

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Abstract

Objective

To determine factors influencing survival and prognosis of HPV-related and non-related oropharyngeal cancer.

Methods

Subjects were determined from the three hospitals in Anhui province of China between 2015 and 2020. Paraffin-embedded specimens from participants’ tissues were analyzed, and the subjects were classified as P16 + and P16 − cases using immunohistochemical staining for P16 protein.

Results

A total of 426 patients with oropharyngeal cancer were recruited in this study; 108 cases were found to be P16 + . The subjects were treated with the three regimens: surgery/radiotherapy/chemotherapy (SRCT), radiotherapy/chemotherapy (RCT), and surgery/chemotherapy (SCT). There were no statistically significant differences in the survival rates within the P16 + or P16 − groups between the three treatment regimens (P > 0.05). The 1-, 3-, and 5-year survival rates for P16 + and P16 − groups were statistically different (P < 0.05). Multivariate analysis showed that age, physical health status, smoking, and alcohol abuse were independent risk factors affecting the prognosis of P16 + cases, while pathological grading and TNM staging were independent risk factors affecting the P16 − cases.

Conclusion

The etiology, pathogenesis, survival status, and prognostic factors of HPV-related oropharyngeal cancer are very different from those of traditional oropharyngeal cancer. Thus, HPV-related oropharyngeal cancer could be classified as a separate type of disease. This distinction could be of great significance for treatment, prevention, and prognostication of oropharyngeal cancer.

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Data Availability

On behalf of all authors, I declare the all data contained in this article are true, valid and usable.

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Funding

This study was supported by the Key Project of Translational Medicine, Bengbu Medical College, Mechanism of interleukin-17 uptake to neutrophils in the progression of oral squamous cell carcinoma (BYTM2019005); the University Cooperative Research and Public Health Collaborative Innovation Project of Anhui Province (GXXT-2020–021).

Author information

Authors and Affiliations

  1. The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, Anhui, China

    Jiancheng Li, Feng Zhuo, Xuji Wang & Yun Guo

  2. Bengbu Medical College, Bengbu, 233030, Anhui, China

    Lina Jiang

Authors
  1. Jiancheng Li
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  2. Feng Zhuo
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  3. Xuji Wang
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  4. Yun Guo
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  5. Lina Jiang
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Contributions

Jiancheng Li: Writing—Original Draft、Methodology、Project administration.

Feng Zhuo: Investigation、 Formal analysis、prepared figures and tables.

Xuji Wang: Writing-Reviewing and Editing.

Yun Guo: Data Collection、Supervision.

Lina Jiang: Project administration、Funding Acquisition.

All authors reviewed the manuscript.

Corresponding author

Correspondence to Lina Jiang.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Ethics Committee of Bengbu Medical College ([2021] No.219), and all the patients gave the informed consent and signed the informed consent form.

Conflict of interest

The authors declare no competing interests.

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Li, J., Zhuo, F., Wang, X. et al. Clinical data, survival, and prognosis of 426 cases of oropharyngeal cancer: a retrospective analysis. Clin Oral Invest 27, 6597–6606 (2023). https://doi.org/10.1007/s00784-023-05265-y

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  • DOI: https://doi.org/10.1007/s00784-023-05265-y

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