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Comparison of the clinical efficacy of concentrated growth factor and advanced platelet-rich fibrin in the treatment of type I multiple gingival recessions: a controlled randomized clinical trial

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Abstract

Objectives

The purpose of this randomized controlled clinical trial was to compare and evaluate the clinical effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) applied together with coronally advanced flap (CAF) technique using a microsurgical approach in the treatment of type I multiple gingival recessions (GR).

Materials and methods

Sixteen patients with multiple recession defects (Cairo type I) were included in this randomized and controlled study. Forty-five gingival recession defects were randomly equally divided into three groups (n = 15): CAF + CGF (test site); CAF + A-PRF (test site), and CAF alone (control site). Clinical attachment level (CAL), vertical gingival recession (VGR), horizontal gingival recession (HGR), gingival thickness (GT), width of keratinized gingiva (KGW), percentages of the mean (MRC), and complete root coverage (CRC), patient esthetic score (PES), and hypersensitivity score (HS) were recorded at baseline and 6 months after surgery. Patient comfort score (PCS) was evaluated at the day of surgery.

Results

Significant improvements were determined in CAL, VGR, HGR, KGW, and GT at 6 months when compared to baseline levels in intra-group comparisons for all groups, and also GT was increased in CAF + A-PRF and CAF + CGF compared to CAF alone at 6 months in intergroup comparisons (p < 0.05). At 6 months, MRC was detected 85.66 ± 22.68% in the CAF + CGF, 90.88 ± 20.87% in the CAF + A-PRF, and 75.10 ± 32,37% in the CAF alone, and a significant increase was detected in the CAF + A-PRF group compared to CAF alone (p < 0.05). CRC in CAF + CGF was 66.66%, in CAF + A-PRF 80% and in CAF alone was 53.33% (p > 0.05). PES and HS values showed significant improvement from baseline to 6 months for all groups and also in CAF + CGF and CAF + A-PRF compared to CAF alone at 6 months in intergroup comparisons (p < 0.05).

Conclusions

The present study showed that the use of A-PRF and CGF membranes in GR therapy may have an additional benefit in GT increase and also A-PRF may increase the percentages of MRC. The use of A-PRF and CGF membranes may be beneficial in terms of improving patient-related parameters.

Clinical relevance

A-PRF and CGF may be superior to CAF alone in terms of patient-related parameters and GT increase in multiple recession defects.

Trial Registration Number: 17578e02-00a9-4a41-8c8d-42a637143531.

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Funding

This study has been supported by the Scientific Research Fund of Ordu University, Ordu, Turkey (Project No: HD-1726).

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Authors and Affiliations

  1. Faculty of Dentistry, Department of Periodontology, Ordu University, 52100, Altınordu. Ordu, Turkey

    Figen Öngöz Dede, Kübra Çelen, Selman Çelen & Emre Taha Deveci

  2. Faculty of Dentistry, Department of Periodontology, Yıldırım Beyazıt University, Ankara, Turkey

    Şeyma Bozkurt Doğan

  3. Faculty of Dentistry, Department of Orthodontics, Ordu University, Ordu, Turkey

    Neslihan Seyhan Cezairli

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  1. Figen Öngöz Dede
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  2. Şeyma Bozkurt Doğan
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Contributions

Study conception and design: F.O.D. and Ş.B.D. Analysis and interpretation of the data: F.O.D., K.Ç., and N.S.C. Data collection: F.O.D., S.Ç., and E.T.D. Drafting of the manuscript: F.O.D. and Ş.B.D. All authors gave their final approval and agreed to be accountable for all aspects of the work.

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Correspondence to Figen Öngöz Dede.

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Competing interests

The authors declare no competing interests.

Ethics approval

The study protocol was confirmed by the Clinical Research Ethics Committee of Ordu University, Ordu, Turkey, according to the Helsinki Declaration of 1975, as revised in 2008 (Protocol ID: 2017–161, Clinical Trial. org- NCT05319938).

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All participants gave their informed consent prior to their inclusion in the study.

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Öngöz Dede, F., Bozkurt Doğan, Ş., Çelen, K. et al. Comparison of the clinical efficacy of concentrated growth factor and advanced platelet-rich fibrin in the treatment of type I multiple gingival recessions: a controlled randomized clinical trial. Clin Oral Invest 27, 645–657 (2023). https://doi.org/10.1007/s00784-022-04775-5

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