Skip to main content

Advertisement

SpringerLink
Log in

Association between sexual maturation and anterior disc displacement of temporomandibular joint in adolescents aged 13–14 years

  • Original Article
  • Published:
Clinical Oral Investigations Aims and scope Submit manuscript

Abstract

Objectives

To investigate the association between sexual maturation and anterior disc displacement (ADD) of temporomandibular joint (TMJ).

Materials and methods

Adolescents aged 13–14 years old, attending the first grade of one private junior school, were recruited. Magnetic resonance imaging (MRI) was used to confirm ADD, in addition, the serum levels of sex hormones were tested. Secondary sex characteristics, psychological evaluations, oral health-related behaviors, and sociodemographic characteristics were also collected.

Results

A total of 440 teenagers were included, of which the prevalence of ADD was 17.7%. Subgroup analysis revealed that age at menarche in girls and nocturnal emission, laryngeal prominence, voice change, and facial hair in boys showed significant differences between the ADD group and the normal population (all p < 0.05). The serum levels of prolactin in girls (12.23 and 9.82 ng/ml) and testosterone in boys (3.65 and 2.48 ng/dl) were significantly higher in the ADD group compared to the normal population, respectively (both p < 0.05).

Conclusions

This study suggested that sexual maturation has a significant association with ADD both in boys and girls. The increased serum levels of testosterone in boys and prolactin in girls might contribute to the occurrence of TMJ ADD.

Clinical relevance

This study provides key data to support and inform longitudinal studies as well as to explain why ADD prefers in adolescents. Main findings can also be used to prevent the occurrence of ADD and secondary jaw deformities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Naeije M, Te Veldhuis AH, Te Veldhuis EC et al (2013) Disc displacement within the human temporomandibular joint: a systematic review of a ‘noisy annoyance.’ J Oral Rehabil 40(2):139–158. https://doi.org/10.1111/joor.12016

    Article  PubMed  Google Scholar 

  2. Ikeda K, Kawamura A, Ikeda R (2014) Prevalence of disc displacement of various severities among young preorthodontic population: a magnetic resonance imaging study. J Prosthodont 23(5):397–401. https://doi.org/10.1111/jopr.12126

    Article  PubMed  Google Scholar 

  3. Huddleston Slater JJ, Lobbezoo F, Onland-Moret NC et al (2007) Anterior disc displacement with reduction and symptomatic hypermobility in the human temporomandibular joint: prevalence rates and risk factors in children and teenagers. J Orofac Pain 21(1):55–62

    PubMed  Google Scholar 

  4. Isberg A, Hägglund M, Paesani D (1998) The effect of age and gender on the onset of symptomatic temporomandibular joint disk displacement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85(3):252–257. https://doi.org/10.1016/s1079-2104(98)90004-x

    Article  PubMed  Google Scholar 

  5. Marpaung C, van Selms MKA, Lobbezoo F (2019) Temporomandibular joint anterior disc displacement with reduction in a young population: prevalence and risk indicators. Int J Paediatr Dent 29(1):66–73. https://doi.org/10.1111/ipd.12426

    Article  PubMed  Google Scholar 

  6. Hall HD, Nickerson JW Jr (1994) Is it time to pay more attention to disc position? J Orofac Pain 8(1):90–96

    PubMed  Google Scholar 

  7. Bryndahl F, Eriksson L, Legrell PE et al (2006) Bilateral TMJ disk displacement induces mandibular retrognathia. J Dent Res 85(12):1118–1123. https://doi.org/10.1177/154405910608501210

    Article  PubMed  Google Scholar 

  8. Xie Q, Yang C, He D et al (2016) Will unilateral temporomandibular joint anterior disc displacement in teenagers lead to asymmetry of condyle and mandible? A longitudinal study J Craniomaxillofac Surg 44(5):590–596. https://doi.org/10.1016/j.jcms.2016.01.019

    Article  PubMed  Google Scholar 

  9. Kalaykova S, Lobbezoo F, Naeije M (2011) Effect of chewing upon disc reduction in the temporomandibular joint. J Orofac Pain 25(1):49–55

    PubMed  Google Scholar 

  10. Spruijt RJ, Wabeke KB (1995) Psychological factors related to the prevalence of temporomandibular joint sounds. J Oral Rehabil 22(11):803–808. https://doi.org/10.1111/j.1365-2842.1995.tb00226.x

    Article  PubMed  Google Scholar 

  11. Nebbe B, Major PW (2000) Prevalence of TMJ disc displacement in a pre-orthodontic adolescent sample. Angle Orthod 70(6):454–463. https://doi.org/10.1043/0003-3219(2000)070%3c0454:Potddi%3e2.0.Co;2

    Article  PubMed  Google Scholar 

  12. Tasaki MM, Westesson PL, Isberg AM et al (1996) Classification and prevalence of temporomandibular joint disk displacement in patients and symptom-free volunteers. Am J Orthod Dentofacial Orthop 109(3):249–262. https://doi.org/10.1016/s0889-5406(96)70148-8

    Article  PubMed  Google Scholar 

  13. Restrepo CC, Suarez N, Moratto N et al (2020) Content and construct validity of the diagnostic criteria for temporomandibular disorders axis I for children. J Oral Rehabil 47(7):809–819. https://doi.org/10.1111/joor.12957

    Article  PubMed  Google Scholar 

  14. Schiffman E, Ohrbach R (2016) Executive summary of the diagnostic criteria for temporomandibular disorders for clinical and research applications. J Am Dent Assoc 147(6):438–445. https://doi.org/10.1016/j.adaj.2016.01.007

    Article  PubMed  PubMed Central  Google Scholar 

  15. Schiffman E, Ohrbach R, Truelove E et al (2014) Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache 28(1):6–27. https://doi.org/10.11607/jop.1151

    Article  PubMed  PubMed Central  Google Scholar 

  16. Matina RM, Rogol AD (2011) Sport training and the growth and pubertal maturation of young athletes. Pediatr Endocrinol Rev 9(1):441–455

    PubMed  Google Scholar 

  17. Patel JS, Oh Y, Rand KL et al (2019) Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005–2016. Depress Anxiety 36(9):813–823. https://doi.org/10.1002/da.22940

    Article  PubMed  PubMed Central  Google Scholar 

  18. Löwe B, Decker O, Müller S et al (2008) Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Med Care 46(3):266–274. https://doi.org/10.1097/MLR.0b013e318160d093

    Article  PubMed  Google Scholar 

  19. Page LA, Thomson WM, Mohamed AR et al (2011) Performance and cross-cultural comparison of the short-form version of the CPQ11-14 in New Zealand, Brunei and Brazil. Health Qual Life Outcomes 9:40. https://doi.org/10.1186/1477-7525-9-40

    Article  PubMed  Google Scholar 

  20. Kroenke K, Spitzer RL, Williams JB (2002) The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med 64(2):258–266. https://doi.org/10.1097/00006842-200203000-00008

    Article  PubMed  Google Scholar 

  21. Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545. https://doi.org/10.1093/sleep/14.6.540

    Article  PubMed  Google Scholar 

  22. Markiewicz MR, Ohrbach R, McCall WD Jr (2006) Oral behaviors checklist: reliability of performance in targeted waking-state behaviors. J Orofac Pain 20(4):306–316

    PubMed  Google Scholar 

  23. Moss RA, Lombardo TW, Hodgson JM et al (1989) Oral habits in common between tension headache and non-headache populations. J Oral Rehabil 16(1):71–74. https://doi.org/10.1111/j.1365-2842.1989.tb01319.x

    Article  PubMed  Google Scholar 

  24. Maspero C, Prevedello C, Giannini L et al (2014) Atypical swallowing: a review. Minerva Stomatol 63(6):217–227

    PubMed  Google Scholar 

  25. Onyeaso CO, Isiekwe MC (2008) Oral habits in the primary and mixed dentitions of some Nigerian children: a longitudinal study. Oral Health Prev Dent 6(3):185–190

    PubMed  Google Scholar 

  26. Ikeda K (2013) A reference line on temporomandibular joint MRI. J Prosthodont 22(8):603–607. https://doi.org/10.1111/jopr.12052

    Article  PubMed  Google Scholar 

  27. Nakagawa S, Sakabe J, Nakajima I et al (2002) Relationship between functional disc position and mandibular displacement in adolescent females: posteroanterior cephalograms and magnetic resonance imaging retrospective study. J Oral Rehabil 29(5):417–422. https://doi.org/10.1046/j.1365-2842.2002.00885.x

    Article  PubMed  Google Scholar 

  28. Gidarakou IK, Tallents RH, Stein S et al (2004) Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reduction. Angle Orthod 74(2):212–219. https://doi.org/10.1043/0003-3219(2004)074%3c0212:Cosadm%3e2.0.Co;2

    Article  PubMed  Google Scholar 

  29. Gidarakou IK, Tallents RH, Kyrkanides S et al (2003) Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement without reduction. Angle Orthod 73(2):121–127. https://doi.org/10.1043/0003-3219(2003)73%3c121:Cosadm%3e2.0.Co;2

    Article  PubMed  Google Scholar 

  30. Kirk WS Jr (1992) Failure of surgical orthodontics due to temporomandibular joint internal derangement and postsurgical condylar resorption. Am J Orthod Dentofacial Orthop 101(4):375–380. https://doi.org/10.1016/s0889-5406(05)80331-2

    Article  PubMed  Google Scholar 

  31. Miernik M, Więckiewicz W (2015) The basic conservative treatment of temporomandibular joint anterior disc displacement without reduction–review. Adv Clin Exp Med 24(4):731–735. https://doi.org/10.17219/acem/35165

    Article  PubMed  Google Scholar 

  32. Liu S, Wang M, Ai T et al (2016) In vivo morphological and functional evaluation of the lateral pterygoid muscle: a diffusion tensor imaging study. Br J Radiol 89(1064):20160041. https://doi.org/10.1259/bjr.20160041

    Article  PubMed  PubMed Central  Google Scholar 

  33. Liu S, Wan C, Li H et al (2022) Diffusion tensor imaging of the lateral pterygoid muscle in patients with temporomandibular joint disorders and healthy volunteers. Korean J Radiol 23(2):218–225. https://doi.org/10.3348/kjr.2021.0132

    Article  PubMed  Google Scholar 

  34. Lin SL, Wu SL, Tsai CC et al (2016) Serum cortisol level and disc displacement disorders of the temporomandibular joint. J Oral Rehabil 43(1):10–15. https://doi.org/10.1111/joor.12331

    Article  PubMed  Google Scholar 

  35. Fischer L, Clemente JT, Tambeli CH (2007) The protective role of testosterone in the development of temporomandibular joint pain. J Pain 8(5):437–442. https://doi.org/10.1016/j.jpain.2006.12.007

    Article  PubMed  Google Scholar 

  36. Fanton LE, Macedo CG, Torres-Chávez KE et al (2017) Activational action of testosterone on androgen receptors protects males preventing temporomandibular joint pain. Pharmacol Biochem Behav 152:30–35. https://doi.org/10.1016/j.pbb.2016.07.005

    Article  PubMed  Google Scholar 

  37. Harbuz MS, Perveen-Gill Z, Lightman SL et al (1995) A protective role for testosterone in adjuvant-induced arthritis. Br J Rheumatol 34(12):1117–1122. https://doi.org/10.1093/rheumatology/34.12.1117

    Article  PubMed  Google Scholar 

  38. Flake NM, Hermanstyne TO, Gold MS (2006) Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint. Am J Physiol Regul Integr Comp Physiol 291(2):R343-348. https://doi.org/10.1152/ajpregu.00835.2005

    Article  PubMed  Google Scholar 

  39. Ganesan K, Balachandran C, Manohar BM et al (2008) Comparative studies on the interplay of testosterone, estrogen and progesterone in collagen induced arthritis in rats. Bone 43(4):758–765. https://doi.org/10.1016/j.bone.2008.05.025

    Article  PubMed  Google Scholar 

  40. Riggs BL, Khosla S, Melton LJ 3rd (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23(3):279–302. https://doi.org/10.1210/edrv.23.3.0465

    Article  PubMed  Google Scholar 

  41. Bernard V, Young J, Binart N (2019) Prolactin - a pleiotropic factor in health and disease. Nat Rev Endocrinol 15(6):356–365. https://doi.org/10.1038/s41574-019-0194-6

    Article  PubMed  Google Scholar 

  42. Clapp C, Adán N, Ledesma-Colunga MG et al (2016) The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: an integrative overview. Cell Mol Life Sci 73(15):2929–2948. https://doi.org/10.1007/s00018-016-2187-0

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank all the children and families that participated in this project. We also thank all the staff and researchers involved in the assessments and the program. This study was supported by the students attending the first grade of private Shangde Experimental School in Shanghai, China, and their parents and teachers. This study was supported by the National Natural Science Foundation of China (81870785 and 82071134), a dominant disease biological sample project of the Ninth People’s Hospital Affiliated with Shanghai Jiao Tong University School of Medicine (YBKA201908).

Funding

This study was supported by the students attending the first grade of private Shangde Experimental School in Shanghai, China, and their parents and teachers. This study was supported by the National Natural Science Foundation of China (81870785 and 82071134), a dominant disease biological sample project of the Ninth People’s Hospital Affiliated with Shanghai Jiao Tong University School of Medicine (YBKA201908).

Author information

Author notes

  1. Pei Shen and Dahe Zhang have contributed equally to this work.

Authors and Affiliations

  1. Department of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Pei Shen, Dahe Zhang, Shan Jin, Yi Luo & Chi Yang

  2. College of Stomatology, Shanghai Jiao Tong University, Shanghai, China

    Pei Shen, Dahe Zhang, Shan Jin, Yi Luo & Chi Yang

  3. National Center for Stomatology, Shanghai, China

    Pei Shen, Dahe Zhang, Shan Jin, Yi Luo & Chi Yang

  4. National Clinical Research Center for Oral Diseases, No. 639, Zhi Zao Ju Road, 200011, Shanghai, China

    Pei Shen, Dahe Zhang, Shan Jin, Yi Luo & Chi Yang

  5. Department of Craniomaxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Alexandria, 21563, Egypt

    Ahmed Abdelrehem

Authors
  1. Pei Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dahe Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ahmed Abdelrehem
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shan Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yi Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chi Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study’s conception and design. Pei Shen contributed to the conception, design, data acquisition, interpretation, and drafted and critically revised the manuscript; Dahe Zhang contributed to the conception, design, data acquisition, interpretation, and statistical analysis; Ahmed Abdelrehem contributed to data acquisition, statistical analysis, and critically revised the manuscript; Shan Jin and Yi Luo contributed to design, data acquisition, and critically revised the manuscript; Chi Yang contributed to conception, design, analysis, interpretation, and drafted and critically revised the manuscript. All authors gave final approval and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Chi Yang.

Ethics declarations

Ethics approval

This study received approval from the Human Research Ethics Committee of Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine (SH9H-2020-T7-1).

Consent to participate

Parents or legal guardians responsible for the participants received written and verbal information about the study. Signed consents were obtained from one of the parents or legal guardians for every participant.

Competing interests

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shen, P., Zhang, D., Abdelrehem, A. et al. Association between sexual maturation and anterior disc displacement of temporomandibular joint in adolescents aged 13–14 years. Clin Oral Invest 26, 7071–7081 (2022). https://doi.org/10.1007/s00784-022-04667-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00784-022-04667-8

Keywords

Search

Navigation