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How is the quality of the available evidence on molar-incisor hypomineralization treatment? An overview of systematic reviews

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Abstract

Objective

This overview analyzed the quality of the systematic reviews (SRs) available on treatments for molar-incisor hypomineralization (MIH).

Material and methods

Six electronic databases were searched (PubMed/MEDLINE, Scopus, Web of Science, LILACS, Brazilian Bibliography of Dentistry and Cochrane Library) until March 2022. Two reviewers independently performed the selection, the quality assessment (Assessment of Multiple Systematic Reviews 2 — AMSTAR-2), and the risk of bias assessment of the SR (Risk of Bias in Systematic Reviews — ROBIS).

Results

Two hundred nine records were retrieved; after removing duplicates and applying the inclusion/exclusion criteria, 5 SRs remained. Three SRs were rated as showing critically low methodological quality and high risk of bias, and two were rated as moderate methodological quality and low risk of bias. The identified treatments that may be suitable for MIH were classified as (1) non-invasive — casein incorporated into toothpaste and sugar-free chewing gum, toothpaste containing arginine, 0.4% stannous fluoride gel; fluoride varnish; (2) micro-invasive — resin sealants for pits and fissures, microabrasion, dental whitening, resin infiltration; (3) invasive — ART restorations, indirect restorations (metal, composite, or ceramic); and (4) mixed intervention — stainless steel crowns.

Conclusion

Despite the considerable number of published papers included in this set of systematic reviews, the evidence supporting the effectiveness of treatments for treating MIH is limited due to the methodological quality and risk of bias of the systematic reviews, as well as the quality of the primary studies (PROSPERO: CRD42020144831).

Clinical relevance

Different treatments have been purposed for MIH treatment, but there is still not enough scientific evidence of good quality for the establishment of a definitive clinical protocol for the treatment of MIH.

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Authors and Affiliations

  1. Departament of Dentistry, State University of Ponta Grossa, Av. General Carlos Cavalcanti, 4748 - Uvaranas, Ponta Grossa, Paraná, CEP 84030-900, Brazil

    Mayara Vitorino Gevert, Renata Soares, Letícia Maira Wambier, Ana Elisa Ribeiro, Letícia Simeoni Avais & Ana Cláudia Rodrigues Chibinski

  2. Departament of Dentistry, Federal University of Paraná, Curitiba, Paraná, Brazil

    Juliana Feltrin de Souza

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  1. Mayara Vitorino Gevert
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Contributions

ACRC and JFS — conceived and designed the analysis. RS, MVG, LMW, and AER — collected the data. RS, MVG, LMW, AER, and LSA — contributed data or analysis tools. ACRC, JFS, RS, MVG, LMW, AER, and LSA — performed the analysis. MVG, RS, and ACRC — wrote the paper.

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Correspondence to Ana Cláudia Rodrigues Chibinski.

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Gevert, M.V., Soares, R., Wambier, L.M. et al. How is the quality of the available evidence on molar-incisor hypomineralization treatment? An overview of systematic reviews. Clin Oral Invest 26, 5989–6002 (2022). https://doi.org/10.1007/s00784-022-04612-9

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