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The resolvin D1 levels before and after periodontal therapy in periodontitis patients

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Abstract

Objective

The aim of this study was to determine the levels of resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva in the patients with periodontitis and healthy subjects, and also to evaluate the effects of non-surgical periodontal treatments (NSPTs) on RVD1 levels.

Materials and methods

Fifteen patients with Stage III Grade B periodontitis (P) and 11 periodontally healthy individuals (H) were included in this study. Clinical periodontal measurements, GCF, and saliva samples were collected from each individual at baseline and 6 weeks after NSPTs in periodontitis group. GCF and saliva levels of RVD1 were analyzed by enzyme-linked immunosorbent assay.

Results

GCF total and concentration levels of RVD1 were significantly lower in the periodontitis group than in the healthy group and significantly increased after NSPTs in periodontitis (p < 0.001). There was no statistically significant difference in saliva RVD1 levels between healthy and periodontitis group and also before and after NSPTs in periodontitis (p > 0.05). Significant negative correlations were found between all periodontal clinical parameters and GCF volume with both GCF total amount and concentrations of RVD1 (p < 0.01). There was a positive correlation between GCF total amount and concentrations of RVD1 (r = 0.762, p < 0.01).

Conclusions

GCF levels of RVD1 might be promising biomarkers for monitoring the susceptibility to periodontitis and predicting periodontal status.

Clinical relevance

RVD1 may be valuable biomarker to observe the healing process after periodontal treatment as increased GCF levels might project clinical improvements post-treatment. Accordingly, observing GCF RVD1 levels might be helpful to determine individuals require further periodontal treatment.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu, Turkey

    Ceren Gokmenoglu, Figen Öngöz Dede, Mehmet Cankat Kara & Varol Çanakçi

  2. Department of Periodontology, Faculty of Dentistry, İstanbul Medipol University, Istanbul, 34810, Turkey

    Emrah Turkmen

  3. İzmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey

    Huriye Erbak Yilmaz

  4. Ingham Institute Applied for Medical Research, Liverpool, Sydney, Australia

    Huriye Erbak Yilmaz

Authors
  1. Ceren Gokmenoglu
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  2. Emrah Turkmen
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  3. Figen Öngöz Dede
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  4. Huriye Erbak Yilmaz
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  5. Mehmet Cankat Kara
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  6. Varol Çanakçi
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Corresponding author

Correspondence to Emrah Turkmen.

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Ethics approval

This research was approved by the Ethics Committee on Clinical Research of Ordu university according to the Declaration of Helsinki (No:2019–159). This study is registered at ClinicalTrials.gov as NCT04496570.

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All subjects were informed about the content and procedures of the research and signed informed consent were received.

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The authors declare no competing interests.

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Gokmenoglu, C., Turkmen, E., Öngöz Dede, F. et al. The resolvin D1 levels before and after periodontal therapy in periodontitis patients. Clin Oral Invest 26, 6379–6385 (2022). https://doi.org/10.1007/s00784-022-04593-9

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  • DOI: https://doi.org/10.1007/s00784-022-04593-9

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