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Association of high-density lipoprotein cholesterol and periodontitis severity in Chinese elderly: a cross-sectional study

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Abstract

Objectives

Periodontitis is a local inflammatory disease of high prevalence worldwide. Increasing evidence has shown its association with cardiovascular diseases. While high-density lipoprotein is an important protective factor in preventing cardiovascular diseases, this study aims to examine whether high-density lipoprotein cholesterol (HDL-C) level is associated with different status of periodontitis.

Materials and methods

A total of 874 Chinese retirees (≥ 60 years of age) with different statuses of periodontitis were enrolled. Periodontal clinical data were collected to define periodontal disease severity (no, mild-moderate, severe). Peripheral blood was collected for serum lipid profile analysis. Linear and logistic regression analysis with adjustment for potential confounders (gender, age, BMI, alcohol intake, exercise frequency, smoking habits) were used to determine the association of periodontitis with HDL-C.

Results

After adjustments for confounders, linear regression analyses revealed a significant relationship between the decreased HDL-C and periodontitis severity (p < 0.05). Although the multivariable-adjusted ORs of decreased HDL-C were not statistically significant, logistic regression analyses showed Chinese elderly with severe periodontitis had higher odds of exhibiting clinically abnormal HDL-C levels than those without periodontitis.

Conclusions

The elderly population with periodontitis showed HDL-C levels significantly lower than those without periodontitis. The severity of periodontitis was positively correlated with serum HDL-C levels.

Clinical relevance

Periodontitis reduces HDL-C level in the elderly population, indicating that oral health should be paid attention to in the prevention and treatment of dyslipidemia.

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Funding

The authors received financial support from Natural Science Foundation of Zhejiang Province (LZY21F030002), the Fundamental Research Funds for the Zhejiang Provincial Universities (2021XZZX033), and China Oral Health Foundation (A2021-008).

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Author notes

  1. Haihua Zhu and Guanchen Ye contributed equally to this work.

Authors and Affiliations

  1. Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, Zhejiang, China

    Haihua Zhu, Guanchen Ye, Yanyi Xie, Fudong Zhu & Qianming Chen

  2. School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China

    Kangqi Zhu

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  1. Haihua Zhu
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  2. Guanchen Ye
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Corresponding author

Correspondence to Qianming Chen.

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Ethical approval

This study was approved by the Ethics Committee of Stomatology Hospital affiliated to Zhejiang University School of Medicine (No.2019-003).

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Written informed consent was obtained from all the participants.

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Zhu, H., Ye, G., Xie, Y. et al. Association of high-density lipoprotein cholesterol and periodontitis severity in Chinese elderly: a cross-sectional study. Clin Oral Invest 26, 4753–4759 (2022). https://doi.org/10.1007/s00784-022-04439-4

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  • DOI: https://doi.org/10.1007/s00784-022-04439-4

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