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Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis

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Abstract

Objective

This systematic review assesses the prevalence of microbial complexes in endodontic-periodontal lesion.

Materials and methods

Nine databases were searched through August 2020. Experts were consulted to indicate additional studies. Studies were blindly selected by two reviewers based on pre-defined eligibility criteria. Studies that evaluated the prevalence of microbial orange and red complexes among patients with endodontic-periodontal lesion were considered eligible. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data.

Results

From 572 articles found on all databases, 11 clinical studies were finally included. The following microorganisms were investigated: P. gingivalis, T. forsythia, T. denticola, F. nucleatum, F. periodonticum, P. micra, P. intermedia, P. nigrescens, S. constellatus, C. gracilis, C. rectus, C. showae and E. nodatum. Considering the orange complex, P. micra, E. nodatum and S. constellatus were prevalent in both root canal and periodontal pockets. P. gingivalis and T. forsythia belonging to the red complex were prevalent only in periodontal pockets. The red complex microorganisms were not found very frequently in root canal.

Conclusions

There is a similarity between the microbiome of root canal and periodontal pockets, with prevalence of the three microorganisms of the orange complex. Two microorganisms from the red complex were prevalent only in periodontal pockets.

Clinical relevance

The prevalence of specific microorganisms in endodontic-periodontal lesion is important to understand the microbiological profile of the patients involved and to correlate it with possible clinical and repair conditions of this pathology.

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Authors and Affiliations

  1. Post-Graduate Program in Dentistry, Faculty of Dentistry, University of Passo Fundo, Av. Brasil Leste, São José, Passo Fundo, RS, 28599052-900, Brazil

    Diego José Gambin

  2. Department of Dentistry, Post-Graduate Program in Dentistry, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, s/n-Trindade, Florianópolis, SC, 88040-900, Brazil

    Filipe Colombo Vitali

  3. Department of Oral Medicine and Prosthodontics, University of Passo Fundo, Av. Brasil Leste, São José, Passo Fundo, RS, 28599052-900, Brazil

    João Paulo De Carli

  4. Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, s/n-Trindade, Florianópolis, SC, 88040-900, Brazil

    Ricardo Ruiz Mazzon

  5. Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas-UNICAMP, Av. LimeiraPiracicaba, AreiãoSP, 90113414-903, Brazil

    Brenda P. F. A. Gomes

  6. Department of Dentistry, Federal University of Santa Catarina (UFSC), Av. Delfino Conti, s/n-Trindade, Florianópolis, SC, 88040-900, Brazil

    Thais Mageste Duque

  7. Department of Periodontics, Faculty of Dentistry, University of Passo Fundo, Av. Brasil Leste, São José, Passo Fundo, RS, 28599052-900, Brazil

    Micheline Sandini Trentin

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  1. Diego José Gambin
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Appendices

Appendix 1

Table 6 Database search strategy
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Appendix 2

Table 7 Excluded studies in phase 2 and the reasons for exclusion (n = 20)
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Gambin, D.J., Vitali, F.C., De Carli, J.P. et al. Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis. Clin Oral Invest 25, 6533–6546 (2021). https://doi.org/10.1007/s00784-021-04164-4

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