Abstract
Aim
The aim of this systematic review was to evaluate the efficacy of immediate implant placement (IIP) compared to implants placed after alveolar ridge preservation (ARP) in terms of clinical, esthetic, and patient-reported outcomes.
Methods
A manual and electronic search (National Library of Medicine) was performed for controlled clinical trials, with at least 12 months of follow-up. Primary outcome variable was implant survival and secondary outcomes were marginal bone level (MBL) (change), pink esthetic score (PES), mid-facial mucosal level (change), papilla index score, complications, and patient-reported outcomes.
Results
A total of 10 publications were included (7 randomized clinical trials and 3 controlled clinical trials). The results from the meta-analyses showed that survival rate was significantly lower in the IIP group compared to ARP group [RR = 0.33; 95% CI (0.14; 0.78); p = 0.01]. No significant differences between the two groups were observed regarding radiographic MBL, PES scores, or mid-facial mucosal level (p > 0.05).
Conclusion
The results from this systematic review and meta-analysis showed that IIP had lower survival rates and similar esthetic results when compared to ARP.
Clinical relevance
Clinicians should weigh the benefits and disadvantages of each intervention to select the optimal timing of implant placement.
Similar content being viewed by others
References
Araújo MG, Lindhe J (2005) Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol 32:212–218. https://doi.org/10.1111/j.1600-051X.2005.00642.x
Vignoletti F, Discepoli N, Müller A, Sanctis M, Muñoz F, Sanz M (2012) Bone modelling at fresh extraction sockets: immediate implant placement versus spontaneous healing: an experimental study in the beagle dog. J Clin Periodontol 39:91–97. https://doi.org/10.1111/j.1600-051X.2011.01803.x
Barone A, Ricci M, Tonelli P, Santini S, Covani U (2013) Tissue changes of extraction sockets in humans: a comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing. Clin Oral Implants Res 24:1231–1237. https://doi.org/10.1111/j.1600-0501.2012.02535.x
Pietrokovski J, Massler M (1967) Alveolar ridge resorption following tooth extraction. J Prosthet Dent 17:21–27
Jung RE, Philipp A, Annen BM, Signorelli L, Thoma DS, Hämmerle CHF, Attin T, Schmidlin P (2013) Radiographic evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial. J Clin Periodontol 40:90–98. https://doi.org/10.1111/jcpe.12027
Karaca Ç, Er N, Gülşahı A, Köseoğlu OT (2015) Alveolar ridge preservation with a free gingival graft in the anterior maxilla: volumetric evaluation in a randomized clinical trial. Int J Oral Maxillofac Surg 44:774–780. https://doi.org/10.1016/j.ijom.2015.01.015
Horváth A, Mardas N, Mezzomo LA, Needleman IG, Donos N (2013) Alveolar ridge preservation. A systematic review. Clin Oral Investig 17:341–363. https://doi.org/10.1007/s00784-012-0758-5
Avila-Ortiz G, Elangovan S, Kramer KWO, Blanchette D, Dawson DV (2014) Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis. J Dent Res 93:950–958. https://doi.org/10.1177/0022034514541127
Cooper LF, Reside GJ, Raes F, Garriga JS, Tarrida L, Wiltfang J, Kern M, Bruyn H (2014) Immediate provisionalization of dental implants placed in healed alveolar ridges and extraction sockets: a 5-year prospective evaluation. Int J Oral Maxillofac Implants 29:709–717
Mangano FG, Mastrangelo P, Luongo F, Blay A, Tunchel S, Mangano C (2017) Aesthetic outcome of immediately restored single implants placed in extraction sockets and healed sites of the anterior maxilla: a retrospective study on 103 patients with 3 years of follow-up. Clin Oral Implants Res 28:272–282. https://doi.org/10.1111/clr.12795
Amorfini L, Migliorati M, Drago S, Silvestrini-Biavati A (2017) Immediately loaded implants in rehabilitation of the maxilla: a two-year randomized clinical trial of guided surgery versus standard procedure. Clin Implant Dent Relat Res 19:280–295. https://doi.org/10.1111/cid.12459
Atieh MA, Payne AGT, Duncan WJ, Cullinan MP (2009) Immediate restoration/loading of immediately placed single implants: is it an effective bimodal approach? Clin Oral Implants Res 20:645–659. https://doi.org/10.1111/j.1600-0501.2009.01725.x
Del Fabbro M, Ceresoli V, Taschieri S et al (2015) Immediate loading of postextraction implants in the esthetic area: systematic review of the literature: immediate implant placement and restoration. Clin Implant Dent Relat Res 17:52–70. https://doi.org/10.1111/cid.12074
Chen ST, Buser D (2014) Esthetic outcomes following immediate and early implant placement in the anterior maxilla--a systematic review. Int J Oral Maxillofac Implants 29(Suppl):186–215
Tonetti MS, Cortellini P, Graziani F, Cairo F, Lang NP, Abundo R, Conforti GP, Marquardt S, Rasperini G, Silvestri M, Wallkamm B, Wetzel A (2017) Immediate versus delayed implant placement after anterior single tooth extraction: the timing randomized controlled clinical trial. J Clin Periodontol 44:215–224. https://doi.org/10.1111/jcpe.12666
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1–e34. https://doi.org/10.1016/j.jclinepi.2009.06.006
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006–1012. https://doi.org/10.1016/j.jclinepi.2009.06.005
Jemt T (1997) Regeneration of gingival papillae after single-implant treatment. Int J Periodontics Restorative Dent 17:326–333
Higgins JPT, Altman DG, Gøtzsche PC et al (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928
Ten Heggeler JMAG, Slot DE, Van der Weijden GA (2011) Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: a systematic review: socket preservation following extraction. Clin Oral Implants Res 22:779–788. https://doi.org/10.1111/j.1600-0501.2010.02064.x
Wells G, O’Connell D, Peterson J Newcastle - Ottawa quality assessment scale cohort studies. WWW Doc 1
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Higgins JPT (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560. https://doi.org/10.1136/bmj.327.7414.557
Block MS, Mercante DE, Lirette D, Mohamed W, Ryser M, Castellon P (2009) Prospective evaluation of immediate and delayed provisional single tooth restorations. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 67:89–107. https://doi.org/10.1016/j.joms.2009.07.009
Grandi T, Guazzi P, Samarani R, Grandi G (2013) Immediate provisionalisation of single post-extractive implants versus implants placed in healed sites in the anterior maxilla: 1-year results from a multicentre controlled cohort study. Eur J Oral Implantol 6:285–295
Raes F, Cosyn J, De Bruyn H (2013) Clinical, aesthetic, and patient-related outcome of immediately loaded single implants in the anterior maxilla: a prospective study in extraction sockets, healed ridges, and grafted sites. Clin Implant Dent Relat Res 15:819–835. https://doi.org/10.1111/j.1708-8208.2011.00438.x
Esposito M, Barausse C, Pistilli R, Jacotti M, Grandi G, Tuco L, Felice P (2015) Immediate loading of post-extractive versus delayed placed single implants in the anterior maxilla: outcome of a pragmatic multicenter randomised controlled trial 1-year after loading. Eur J Oral Implantol 8:347–358
Felice P, Pistilli R, Barausse C, Trullenque-Eriksson A, Esposito M (2015) Immediate non-occlusal loading of immediate post-extractive versus delayed placement of single implants in preserved sockets of the anterior maxilla: 1-year post-loading outcome of a randomised controlled trial. Eur J Oral Implantol 8:361–372
Guarnieri R, Belleggia F, Grande M (2016) Immediate versus delayed treatment in the anterior maxilla using single implants with a laser-microtextured collar: 3-year results of a case series on hard- and soft-tissue response and esthetics. J Prosthodont Off J Am Coll Prosthodont 25:135–145. https://doi.org/10.1111/jopr.12295
Slagter KW, Meijer HJA, Bakker NA, Vissink A, Raghoebar GM (2016) Immediate single-tooth implant placement in bony defects in the esthetic zone: a 1-year randomized controlled trial. J Periodontol 87:619–629. https://doi.org/10.1902/jop.2016.150417
Esposito M, Zucchelli G, Cannizzaro G, Checchi L, Barausse C, Trullenque-Eriksson A, Felice P (2017) Immediate, immediate-delayed (6 weeks) and delayed (4 months) post-extractive single implants: 1-year post-loading data from a randomised controlled trial. Eur J Oral Implantol 10:11–26
Checchi V, Felice P, Zucchelli G, Barausse C, Piattelli M, Pistilli R, Grandi G, Esposito M (2017) Wide diameter immediate post-extractive implants vs delayed placement of normal-diameter implants in preserved sockets in the molar region: 1-year post-loading outcome of a randomised controlled trial. Eur J Oral Implantol 10:263–278
Tallarico M, Xhanari E, Pisano M, Gatti F, Meloni SM (2017) Molar replacement with 7 mm-wide diameter implants: to place the implant immediately or to wait 4 months after socket preservation? 1 year after loading results from a randomised controlled trial. Eur J Oral Implantol 10:169–178
De Rouck T, Eghbali R, Collys K et al (2009) The gingival biotype revisited: transparency of the periodontal probe through the gingival margin as a method to discriminate thin from thick gingiva. J Clin Periodontol 36:428–433. https://doi.org/10.1111/j.1600-051X.2009.01398.x
Fürhauser R, Florescu D, Benesch T, Haas R, Mailath G, Watzek G (2005) Evaluation of soft tissue around single-tooth implant crowns: the pink esthetic score: esthetic score. Clin Oral Implants Res 16:639–644. https://doi.org/10.1111/j.1600-0501.2005.01193.x
Van Der Meulen MJ, John MT, Naeije M, Lobbezoo F (2012) Developing abbreviated OHIP versions for use with TMD patients: ABBREVIATED DUTCH OHIP VERSIONS. J Oral Rehabil 39:18–27. https://doi.org/10.1111/j.1365-2842.2011.02242.x
Buser D, Chappuis V, Belser UC, Chen S (2017) Implant placement post extraction in esthetic single tooth sites: when immediate, when early, when late? Periodontol 2000 73:84–102. https://doi.org/10.1111/prd.12170
Morton D, Chen S, Martin W et al (2014) Consensus statements and recommended clinical procedures regarding optimizing esthetic outcomes in implant dentistry. Int J Oral Maxillofac Implants 29:186–215. https://doi.org/10.11607/jomi.2013.g3
Apostolopoulos P, Darby I (2017) Retrospective success and survival rates of dental implants placed after a ridge preservation procedure. Clin Oral Implants Res 28:461–468. https://doi.org/10.1111/clr.12820
Kuchler U, Chappuis V, Gruber R, Lang NP, Salvi GE (2016) Immediate implant placement with simultaneous guided bone regeneration in the esthetic zone: 10-year clinical and radiographic outcomes. Clin Oral Implants Res 27:253–257. https://doi.org/10.1111/clr.12586
Ketabi M, Deporter D, Atenafu EG (2016) A systematic review of outcomes following immediate molar implant placement based on recently published studies: immediate molar implants: a review. Clin Implant Dent Relat Res 18:1084–1094. https://doi.org/10.1111/cid.12390
Kim J-K, Yoon H-J (2017) Clinical and radiographic outcomes of immediate and delayed placement of dental implants in molar and premolar regions: KIM et al. Clin Implant Dent Relat Res 19:703–709. https://doi.org/10.1111/cid.12496
Hattingh A, Hommez G, De Bruyn H et al (2018) A prospective study on ultra-wide diameter dental implants for immediate molar replacement. Clin Implant Dent Relat Res 20:1009–1015. https://doi.org/10.1111/cid.12666
Palattella P, Torsello F, Cordaro L (2008) Two-year prospective clinical comparison of immediate replacement vs. immediate restoration of single tooth in the esthetic zone. Clin Oral Implants Res 19:1148–1153. https://doi.org/10.1111/j.1600-0501.2008.01578.x
Rieder D, Eggert J, Krafft T, Weber HP, Wichmann MG, Heckmann SM (2016) Impact of placement and restoration timing on single-implant esthetic outcome - a randomized clinical trial. Clin Oral Implants Res 27:e80–e86. https://doi.org/10.1111/clr.12539
Schropp L, Wenzel A (2016) Timing of single implant placement and long-term observation of marginal bone levels. Eur J Oral Implantol 9(Suppl 1):S107–S122
Cosyn J, De Lat L, Seyssens L et al (2019) The effectiveness of immediate implant placement for single tooth replacement compared to delayed implant placement: a systematic review and meta-analysis. J Clin Periodontol 46:224–241. https://doi.org/10.1111/jcpe.13054
Yan Q, Xiao L-Q, Su M-Y, Mei Y, Shi B (2016) Soft and hard tissue changes following immediate placement or immediate restoration of single-tooth implants in the esthetic zone: a systematic review and meta-analysis. Int J Oral Maxillofac Implants 31:1327–1340
Cosyn J, Eghbali A, Hermans A, Vervaeke S, de Bruyn H, Cleymaet R (2016) A 5-year prospective study on single immediate implants in the aesthetic zone. J Clin Periodontol 43:702–709. https://doi.org/10.1111/jcpe.12571
Kan JYK, Rungcharassaeng K, Lozada JL, Zimmerman G (2011) Facial gingival tissue stability following immediate placement and provisionalization of maxillary anterior single implants: a 2- to 8-year follow-up. Int J Oral Maxillofac Implants 26:179–187
Raes F, Cosyn J, Crommelinck E, Coessens P, de Bruyn H (2011) Immediate and conventional single implant treatment in the anterior maxilla: 1-year results of a case series on hard and soft tissue response and aesthetics: immediate and conventional single implants. J Clin Periodontol 38:385–394. https://doi.org/10.1111/j.1600-051X.2010.01687.x
Araújo MG, Lindhe J (2009) Ridge alterations following tooth extraction with and without flap elevation: an experimental study in the dog. Clin Oral Implants Res. https://doi.org/10.1111/j.1600-0501.2008.01703.x
van Nimwegen WG, Raghoebar GM, Zuiderveld EG, Jung RE, Meijer HJA, Mühlemann S (2018) Immediate placement and provisionalization of implants in the aesthetic zone with or without a connective tissue graft: a 1-year randomized controlled trial and volumetric study. Clin Oral Implants Res 29:671–678. https://doi.org/10.1111/clr.13258
Zuiderveld EG, Meijer HJA, Vissink A, Raghoebar GM (2018) The influence of different soft-tissue grafting procedures at single implant placement on esthetics: a randomized controlled trial: soft-tissue grafting in single implant sites. J Periodontol 89:903–914. https://doi.org/10.1002/JPER.18-0061
Migliorati M, Amorfini L, Signori A, Biavati AS, Benedicenti S (2015) Clinical and aesthetic outcome with post-extractive implants with or without soft tissue augmentation: a 2-year randomized clinical trial: post-extractive implants: 2-year evaluation. Clin Implant Dent Relat Res 17:983–995. https://doi.org/10.1111/cid.12194
Eghbali A, Seyssens L, De Bruyckere T et al (2018) A 5-year prospective study on the clinical and aesthetic outcomes of alveolar ridge preservation and connective tissue graft at the buccal aspect of single implants. J Clin Periodontol 45:1475–1484. https://doi.org/10.1111/jcpe.13018
Caneva M, Botticelli D, Rossi F, Cardoso LC, Pantani F, Lang NP (2012) Influence of implants with different sizes and configurations installed immediately into extraction sockets on peri-implant hard and soft tissues: an experimental study in dogs. Clin Oral Implants Res 23:396–401. https://doi.org/10.1111/j.1600-0501.2011.02310.x
Funding
This study was self-funded.
Author information
Authors and Affiliations
Contributions
All authors have made substantial contributions to the conception and design of the study. SM and CV have been involved in literature search, data extraction, and data analysis. PC-B and JL-M have been involved in data interpretation. JB and JN have been involved in supervision and final manuscript revision.
Corresponding author
Ethics declarations
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent
For this type of study, formal consent is not required.
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Rights and permissions
About this article
Cite this article
Mareque, S., Castelo-Baz, P., López-Malla, J. et al. Clinical and esthetic outcomes of immediate implant placement compared to alveolar ridge preservation: a systematic review and meta-analysis. Clin Oral Invest 25, 4735–4748 (2021). https://doi.org/10.1007/s00784-021-03986-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00784-021-03986-6