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Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a randomized controlled clinical trial

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Abstract

Aim

To compare the outcomes of modified coronally advanced flap (mCAF) combined with either xenogeneic dermal matrix (XDM) or connective tissue graft (CTG) for the treatment of multiple adjacent gingival recessions (MAGRs).

Materials and methods

Forty-two patients, in whom 130 maxillary (MAGRs) of type (RT1) were found, were randomly allocated to the two groups. Clinical, esthetic, and patient-centered outcomes were evaluated at baseline, 6, and 12 months post-treatment.

Result

Group CAF+ CTG exhibited a higher mean root coverage value (mRC) (91.79%) (primary outcome variable) than group CAF+XDM (80.19%) without statistically significant difference at 12 months (p=0.06). The control group also had significantly higher percentage of teeth in which complete root coverage (CRC) and mean gain of gingival thickness (GT) were achieved, than the test group (p<0.05). With respect to patient-centered outcomes, patients of the test group reported having experienced significantly less pain than those of the control group until 7 days (p<0.05). Both surgical approaches were capable of significantly decreasing dentin hypersensitivity (p<0.05). No difference between groups was found in the esthetic score analysis (p>0.05). Mean surgical time was lower in the test group (p<0.05).

Conclusion

The two treatments showed similar mRC. However, CAF+CTG was superior to CAF+XDM in providing CRC and in gaining GT. CAF+XDM demonstrated advantages over CAF+CTG with regard to patient morbidity and surgical time.

Clinical relevance

Application of XDM provided a better patient experience and shortened the time to recovery after coronally advanced flaps for coverage of multiple adjacent recessions. However, CTG resulted in improved percentages of complete root coverage.

Trial registration

Brazilian Clinical Trials Registry (REBEC) number: RBR-974c9j

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Authors and Affiliations

  1. Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos, SP, Brazil

    Jonathan Meza-Mauricio, Jônatas Cortez-Gianezzi & Marcelo de Faveri

  2. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA

    Poliana Mendes Duarte

  3. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, USA

    Lorenzo Tavelli & Giulio Rasperini

  4. Department of Biomedical, Surgical and Dental Sciences, Foundation IRCCS Ca’ Granda Polyclinic, Milan, Italy

    Giulio Rasperini

Authors
  1. Jonathan Meza-Mauricio
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  2. Jônatas Cortez-Gianezzi
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  3. Poliana Mendes Duarte
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  4. Lorenzo Tavelli
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  5. Giulio Rasperini
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  6. Marcelo de Faveri
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Contributions

All the authors have made substantial contributions to the conception and design of the study. JMM was involved in data collection. MF and PMD were involved in data interpretation. JMM, JG, PMD, LT, GR, and MF were involved in drafting the manuscript. All the authors critically revised and approved the final version of the manuscript to be published.

Corresponding author

Correspondence to Marcelo de Faveri.

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Ethical approval

The study was conducted in compliance with the principles outlined in the experimentation involving human subjects in the Declaration of Helsinki of the World Medical Association (2013). The study protocol was reviewed and approved by the Research Ethics Committee of the School of Dentistry of the University of Guarulhos (protocol CAAE 74045317.7.0000.5506), and registered at ensaiosclinicos.gov.br (RBR-974c9j).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

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Meza-Mauricio, J., Cortez-Gianezzi, J., Duarte, P.M. et al. Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a randomized controlled clinical trial. Clin Oral Invest 25, 6919–6929 (2021). https://doi.org/10.1007/s00784-021-03982-w

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  • DOI: https://doi.org/10.1007/s00784-021-03982-w

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