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Vital pulp therapy in carious pulp–exposed permanent teeth: an umbrella review

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Abstract

Objective

There has been increasing evidence indicating rather high success rates of vital pulp therapies. This umbrella review aimed to provide an overview of existing systematic reviews regarding the outcomes of vital pulp therapy, specifically direct pulp capping, partial pulpotomy and full pulpotomy, in carious pulp–exposed permanent human teeth.

Materials and methods

The specific PICO questions were as follows: Population - permanent human teeth with carious pulp exposure; Intervention - direct pulp capping with pulp capping materials; Comparators - partial pulpotomy and full pulpotomy; Outcomes - success rate and prognostic factors. PubMed, Ovid and Cochrane databases were searched in conjunction with hand searching. Grey literature was searched too. Study selection, data extraction and study appraisal were performed independently by two authors. A consensus was reached through discussion when disagreements arose.

Results

Six articles fulfilled the inclusion criteria. Higher and more predictable success rates of ≥ 2 years were observed for partial pulpotomy and full pulpotomy in carious pulp–exposed permanent human teeth as compared to direct pulp capping. Possible prognostic factors (pre-operative pulp status, pulp capping material and apex closure) yielded conflicting results. Restorative material, periapical status at baseline, final irrigation solution, age and study type did not seem to affect the treatment outcome.

Conclusions

Vital pulp therapy is a reliable treatment option for permanent teeth with carious pulp exposure. However, more high-quality studies are required to corroborate this finding.

Clinical relevance

Vital pulp therapy could be considered as an alternative for root canal treatment for carious pulp–exposed permanent teeth.

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References

  1. Gesi A, Bergenholtz G (2003) Pulpectomy – studies on outcome. Endod Top 5:57–70

    Article  Google Scholar 

  2. Ng YL, Mann V, Rahbaran S, Lewsey J, Gulabivala K (2008) Outcome of primary root canal treatment: systematic review of the literature—part 2: Influence of clinical factors. Int Endod J 41:6–31

    Article  PubMed  Google Scholar 

  3. Caplan DJ, Cai J, Yin G, White BA (2005) Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times. J Public Health Dent 65:90–96

    Article  PubMed  Google Scholar 

  4. Pitt Ford TR (2004) Dental pulp. In: Pitt Ford TR (ed) Harty’s endodontics in clinical practice, 5th edn. Wright, Edinburgh, pp 37–49

    Google Scholar 

  5. Swift EJ Jr, Trope M, Ritter AV (2003) Vital pulp therapy for mature tooth: can it work? Endod Top 5:49–56

    Article  Google Scholar 

  6. American Association of Endodontists (2020) Glossary of Endodontic Terms Tenth Edition

  7. Mejàre I, Cvek M (1993) Partial pulpotomy in young permanent teeth with deep carious lesions. Endod Dent Traumatol 9:238–242

    Article  PubMed  Google Scholar 

  8. Caliskan MK (1995) Pulpotomy of carious vital teeth with periapical involvement. Int Endod J 28:172–176

    Article  PubMed  Google Scholar 

  9. Dammaschke T, Leidinger J, Schäfer E (2010) Long-term evaluation of direct pulp capping — treatment outcomes over an average period of 6.1 years. Clin Oral Investig 14:559–567

    Article  PubMed  Google Scholar 

  10. Ward J (2002) Vital pulp therapy in cariously exposed permanent teeth and its limitations. Aust Endod J 28:29–37

    Article  PubMed  Google Scholar 

  11. Asgary S, Eghbal MJ, Ghoddusi J (2014) Two-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter randomized clinical trial. Clin Oral Investig 18:635–641

    Article  PubMed  Google Scholar 

  12. Schwendicke F, Stolpe M (2014) Direct pulp capping after a carious exposure versus root canal treatment: a cost-effectiveness analysis. J Endod 40:1764–1770

    Article  PubMed  Google Scholar 

  13. Wells C, Dulong C, McCormack S (2019) Vital pulp therapy for endodontic treatment of mature teeth: a review of clinical effectiveness, cost-effectiveness, and guidelines. Canadian Agency for Drugs and Technologies in Health, Ottawa

    Google Scholar 

  14. The Centre for Evidence-Based Medicine (2009) Oxford Centre for Evidence-Based Medicine: Levels of Evidence (March 2009). https://www.cebm.ox.ac.uk/resources/levels-of-evidence/oxford-centre-for-evidence-based-medicine-levels-of-evidence-march-2009. Accessed 02 November 2020.

  15. Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P (2015) Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Int J Evid Based Healthc 13:132–140

    Article  Google Scholar 

  16. Aromataris E, Fernandez R, Godfrey C, Holly C, Khalil H, Tungpunkom P (2020) Chapter 10: umbrella reviews. In: Aromataris E, Munn Z (eds) JBI manual for evidence synthesis. JBI. https://doi.org/10.46658/JBIMES-20-11

    Chapter  Google Scholar 

  17. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 151:264–269

    Google Scholar 

  18. Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, Henry DA (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomized or non-randomized studies of healthcare interventions, or both. BMJ 358:j4008

    Article  PubMed  PubMed Central  Google Scholar 

  19. Aguilar P, Linsuwanont P (2011) Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 37:581–587

    Article  PubMed  Google Scholar 

  20. Alqaderi H, Lee CT, Borzangy S, Pagonis TC (2016) Coronal pulpotomy for cariously exposed permanent posterior teeth with closed apices: a systematic review and meta-analysis. J Dent 44:1–7

    Article  PubMed  Google Scholar 

  21. Brodén J, Heimdal H, Josephsson O, Fransson H (2016) Direct pulp capping versus root canal treatment in young permanent vital teeth with pulp exposure due to caries. A systematic review. Am J Dent 29:201–207

    PubMed  Google Scholar 

  22. Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, Clarke M, El Karim IA (2019) Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: a systematic review. J Dent 88:103158

    Article  PubMed  Google Scholar 

  23. Elmsmari F, Ruiz XF, Miró Q, Feijoo-Pato N, Durán-Sindreu F, Olivieri JG (2019) Outcome of partial pulpotomy in cariously exposed posterior permanent teeth: a systematic review and meta-analysis. J Endod 45:1296–1306

    Article  PubMed  Google Scholar 

  24. Li Y, Sui B, Dahl C, Bergeron B, Shipman P, Niu L, Chen J, Tay FR (2019) Pulpotomy for carious pulp exposures in permanent teeth: a systematic review and meta-analysis. J Dent 84:1–8

    Article  PubMed  Google Scholar 

  25. Dummer PM, Hicks R, Huws D (1980) Clinical signs and symptoms in pulp disease. Int Endod J 13:27–35

    Article  PubMed  Google Scholar 

  26. Ricucci D, Loghin S, Siqueira JF Jr (2014) Correlation between clinical and histologic pulp diagnoses. J Endod 40:1932–1939

    Article  PubMed  Google Scholar 

  27. Seltzer S, Bender IB, Ziontz M (1963) The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg Oral Med Oral Pathol 16:846–871

    Article  PubMed  Google Scholar 

  28. Schmalz G, Smith AJ (2014) Pulp development, repair, and regeneration: challenges of the transition from traditional dentistry to biologically based therapies. J Endod 40:S2–S5

    Article  PubMed  Google Scholar 

  29. Qudeimat MA, Alyahya A, Hasan AA (2017) Mineral trioxide aggregate pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study. Int Endod J 50:126–134

    Article  PubMed  Google Scholar 

  30. Taha NA, Khazali MA (2017) Partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial. J Endod 43:1417–1421

    Article  PubMed  Google Scholar 

  31. Fong CD, Davis MJ (2002) Partial pulpotomy for immature permanent teeth, its present and future. Pediatr Dent 24:29–32

    PubMed  Google Scholar 

  32. Matsuo T, Nakanishi T, Shimizu H, Ebisu S (1996) A clinical study of direct pulp capping applied to carious-exposed pulps. J Endod 22:551–556

    Article  PubMed  Google Scholar 

  33. Witherspoon DE, Small JC, Harris GZ (2006) Mineral trioxide aggregate pulpotomies: a case series outcomes assessment. J Am Dent Assoc 137:610–618

    Article  PubMed  Google Scholar 

  34. Massler M (1972) Therapy conductive to healing of the human pulp. Oral Surg Oral Med Oral Pathol 34:122–130

    Article  PubMed  Google Scholar 

  35. Simon S, Perard M, Zanini M, Smith AJ, Charpentier E, Djole SX, Lumley PJ (2013) Should pulp chamber pulpotomy be seen as a permanent treatment? Some preliminary thoughts. Int Endod J 46:79–87

    Article  PubMed  Google Scholar 

  36. Berk H, Krakow AA (1972) A comparison of the management of pulpal pathosis in deciduous and permanent teeth. Oral Surg Oral Med Oral Pathol 34:944–955

    Article  PubMed  Google Scholar 

  37. Cvek M (1978) A clinical report on partial pulpotomy and capping with calcium hydroxide in permanent incisors with complicated crown fracture. J Endod 4:232–237

    Article  PubMed  Google Scholar 

  38. Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bjørndal L (2019) European Society of Endodontology position statement: management of deep caries and the exposed pulp. Int Endod J 52:923–934

    Article  PubMed  Google Scholar 

  39. McGrath C, Bedi R (1999) The value and use of ’quality of life’ measures in the primary dental care setting. Prim Dent Care 6:53–57

    PubMed  Google Scholar 

  40. Allen PF (2003) Assessment of oral health related quality of life. Health Qual Life Outcomes 1:40

    Article  PubMed  PubMed Central  Google Scholar 

  41. Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW (2015) Methods for the economic evaluation of health care programmes, 4th edn. Oxford University Press, New York

    Google Scholar 

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Correspondence to Dephne Jack Xin Leong.

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Leong, D.J.X., Yap, A.U. Vital pulp therapy in carious pulp–exposed permanent teeth: an umbrella review. Clin Oral Invest 25, 6743–6756 (2021). https://doi.org/10.1007/s00784-021-03960-2

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