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The combined use of systemic analgesic/anti-inflammatory drugs and a bioactive topical desensitizer for reduced in-office bleaching sensitivity without jeopardizing the hydrogen peroxide efficacy: a randomized, triple blinded, split-mouth clinical trial

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Abstract

Objective

To evaluate the effect of combined systemic administration of paracetamol 500 mg/codeine phosphate 30 mg (PACO) and postoperative topical application of a bioactive desensitizer on in-office bleaching sensitivity and tooth color change.

Materials and methods

A randomized, triple-blind, split-mouth clinical trial was conducted. Forty volunteers ingested PACO (n = 20) or placebo (PLA) (n = 20). Their left/right hemiarches received topical application of a bioactive desensitizer [Nano-P™(NP)] and prophylactic paste (PAS), generating four treatment approaches: PACO/NP, PACO/PAS, PLA/NP, and PLA/PAS. Two bleaching sessions (35% hydrogen peroxide) were performed, and the PAS/NP were applied after the procedure. Sensitivity was obtained since the first bleaching session up to 7 days post-bleaching. The color change was evaluated using CIEDE2000 and whiteness index parameters up to 7 days post-bleaching. Data were analyzed using one- and two-way ANOVA/Tukey post hoc tests (p < 0.05).

Results

The PLA/PAS showed a sensitivity average of at least two times higher than the PACO/NP. The treatment approaches promoted statistically similar bleaching patterns (p > 0.05).

Conclusion

The combined approach of systemic administration of PACO and postoperative topical application of NP reduced the level of in-office bleaching sensitivity without jeopardizing hydrogen peroxide efficacy.

Clinical relevance

Professionals can adopt the combined approach of systemic administration of analgesic/anti-inflammatory drugs and topical application of a bioactive desensitizer for decreased bleaching sensitivity caused by 35% hydrogen peroxide in-office.

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Funding

This work was supported by the Coordination for the Improvement of Higher Education Personnel (CAPES) (grant 88882.375243/2019-01) and the National Council for Scientific and Technological Development (CNPq) (grant number: 131249/2020-7).

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Authors and Affiliations

  1. Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Brazil

    Isabela Dantas Torres de Araújo, Kaiza de Sousa Santos, Thauan Victor Oliveira das Neves Peixoto, Moan Jéfter Fernandes Costa, Isauremi Vieira de Assunção & Boniek Castillo Dutra Borges

  2. Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Av. Sen. Salgado Filho, 1787, Lagoa Nova, Natal, RN, Brazil

    Boniek Castillo Dutra Borges

Authors
  1. Isabela Dantas Torres de Araújo
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  2. Kaiza de Sousa Santos
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  3. Thauan Victor Oliveira das Neves Peixoto
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  4. Moan Jéfter Fernandes Costa
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  5. Isauremi Vieira de Assunção
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  6. Boniek Castillo Dutra Borges
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Corresponding author

Correspondence to Boniek Castillo Dutra Borges.

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Research involving human participants

This study’s research protocol was approved by the Federal University of Rio Grande do Norte (UFRN) institution’s ethics committee (grant number: 3.948.972) and registered at the Brazilian clinical trials database (REBEC) (RBR-54xy8b). The research was reported following the CONSORT 2010 (Consolidated Standards of Reporting Trials Statement) standards.

Informed consent

Before enrolling patients in the trial, an informed consent was obtained by asking prospective patients to read and sign a form containing all information regarding the treatment’s risks and benefits.

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The authors declare no competing interests.

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de Araújo, I.D.T., de Sousa Santos, K., das Neves Peixoto, T.V.O. et al. The combined use of systemic analgesic/anti-inflammatory drugs and a bioactive topical desensitizer for reduced in-office bleaching sensitivity without jeopardizing the hydrogen peroxide efficacy: a randomized, triple blinded, split-mouth clinical trial. Clin Oral Invest 25, 6623–6632 (2021). https://doi.org/10.1007/s00784-021-03948-y

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