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Clinical evaluation of the treatment of multiple gingival recessions with connective tissue graft or concentrated growth factor using tunnel technique: a randomized controlled clinical trial

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Abstract

Objective

To assess the effectiveness of the combination of tunnel technique (TT) and concentrated growth factor (CGF) for root coverage in treating multiple gingival recessions (GR) and compare with the connective tissue graft (CTG).

Materials and methods

Forty patients with Miller Class I and II maxillary or mandibular GR were randomly divided into two groups as follows: TT + CTG and TT + CGF. The results at baseline and 6 months were evaluated for the following clinical parameters: complete root coverage (CRC), mean root coverage (MRC), gingival thickness (GT), gingival recession width (RW), gingival recession depth (RD), and keratinized tissue width (KTW).

Results

At 6 months, a statistically significant difference was found in RD, RW, MRC, CRC, KTW, and GT compared with the baseline (p < 0.05). MRC was determined 89.52±16.36% in the TT + CTG and 76.60±24.10% in the TT + CGF (p < 0.05). CRC was achieved in 66.7% of the TT + CTG and 47.4% of the TT + CGF (p < 0.05). The increase in KTW and GT was significantly better in the TT + CTG group compared to the TT + CGF (p < 0.05).

Conclusions

The study showed that TT + CGF did not improve the results as much as TT + CTG in the treatment of Miller Class I and II GR. However, this finding is not sufficient to advocate the true clinical effects of CGF on GR treatment with TT.

Clinical relevance

CGF could not serve as a direct alternative biomaterial to the gold standard CTG.

Trial registration

ClinicalTrials.gov Identification Number: NCT04561947

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Acknowledgements

The authors do not have any financial interest in the companies whose materials are included in this study.

Funding

This study was supported by the Scientific Research Fund of Bulent Ecevit University in Zonguldak/TURKEY (Project Number: 2017-62550515-01).

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Bulent Ecevit University, Zonguldak, Turkey

    Birsen Korkmaz

  2. Department of Periodontology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey

    Umut Balli

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Contributions

All authors have made substantial contributions to conception and design of the study. BK contributed to the design of the study, treated the patients, analyzed the data, and wrote the manuscript with input from the other author. UB was involved in data collection and interpretation, and revised it critically. All authors have given final approval of the version to be published.

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Correspondence to Birsen Korkmaz.

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Korkmaz, B., Balli, U. Clinical evaluation of the treatment of multiple gingival recessions with connective tissue graft or concentrated growth factor using tunnel technique: a randomized controlled clinical trial. Clin Oral Invest 25, 6347–6356 (2021). https://doi.org/10.1007/s00784-021-03935-3

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