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Anti-inflammatory effect of salt water and chlorhexidine 0.12% mouthrinse after periodontal surgery: a randomized prospective clinical study

Abstract

Objectives

The purpose of this study was to compare the anti-inflammatory efficacy of sodium chloride- and a 0.12% chlorhexidine mouth rinses in patients undergoing minimal invasive periodontal surgery.

Materials and methods

Forty-seven patients with a diagnosis of periodontitis and indication for access flap procedure were randomly selected. Group A: a sodium chloride (salt)water-based mouth rinse (test group) or group B: a 0.12% chlorhexidine mouth rinse (control group) administered after surgery. Gingival Index (GI) were evaluated in the whole mouth and in the surgical site at baseline (T1), a week later (T2), and 12 weeks (T3) after the treatment. Total MMP activity was measured in GCF using a commercial kit and plate reader. Medians of total MMP activity and GI were compared for time intervals T1 vs. T2, T1 vs. T3, and T2 vs T3 using Friedman tests and Wilcoxon signed rank tests, and were also compared between test and control using Mann-WhitneyU tests at each timepoint.

Results

The average GI values showed significant differences between baseline and T2 (p = 0.0005) and baseline and T3 (p = 0.003) in the test group.

Conclusion

The sodium chloride-mouth rinse use after periodontal surgery seems to have similar anti-inflammatory properties as CHX mouth rinse and can be used regularly postoperatively after periodontal surgical procedures.

Clinical relevance

The use of salt water mouthwash showed an anti-inflammatory effect similar to CHX 0.12% after minimal invasive periodontal surgery. Salt water mouthwash is accessible to the world population and can contribute on the healing process after periodontal surgery.

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Funding

This study was funded by the Pontifcia Universidad Católica Madre y Maestra and a competitive fund (V Competitive Research Fund, PUCMM 2014–2015), Santo Domingo, Dominican Republic.

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Correspondence to James Rudolph Collins.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in this study were in accordance with the ethical consideration of the Institutional Review Boards, Bioethics Committee Faculty of Health Sciences Pontificia Universidad Católica Madre y Maestra (COBE-FACS-EST-CSTA-001-3-2014-2015) and with the Declaration of Helsinki (1975), as revised in 2013.

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All subjects signed an informed consent before enrolment.

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Collins, J.R., Veras, K., Hernández, M. et al. Anti-inflammatory effect of salt water and chlorhexidine 0.12% mouthrinse after periodontal surgery: a randomized prospective clinical study. Clin Oral Invest 25, 4349–4357 (2021). https://doi.org/10.1007/s00784-020-03748-w

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  • DOI: https://doi.org/10.1007/s00784-020-03748-w

Keywords

  • Antiplaque agents
  • Anti-inflammatory agents
  • Sodium chloride
  • Chlorhexidine
  • Matrix metalloproteinases
  • Periodontal surgery