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Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis

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Abstract

Objective

A systematic review and meta-analysis was carried out to verify evidence regarding the efficacy and safety of the clinical applicability of natural products in the prevention and treatment of oral mucositis induced by chemotherapy and/or radiotherapy.

Methodology

An electronic research according to the PICOS strategy, using the terms “natural products” and “oral mucositis,” was carried out at Pubmed, Cochrane, Embase, and “gray literature.” The stages of eligibility, data extraction, and quality assessment of the studies were carried out independently and in duplicate.

Results

The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. The included clinical trials covered a variety of 31 types of natural products. Considering the risk of bias of the clinical trials, 24 studies (51.1%) were considered to have a low overall risk of bias, nine (19.1%) were at moderate risk, and 14 clinical trials (29.8%) were at high risk of bias. Honey was the most assessed natural agent. Fourteen studies (3.4%) reported that natural agents reduced pain.

Conclusion

The results of the meta-analysis support a positive effect of honey and Aloe vera in reducing mucositis in patients receiving cancer therapy.

Clinical relevance

The results found add relevant information to the scientific community regarding the prevention and treatment of mucositis.

Graphical abstract

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The work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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  1. Department of Preventive and Clinical Odontology, Post-graduate Program in Odontology, Universidade Federal de Pernambuco, Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil

    Ingrid Carla Guedes da Silva Lima, Laura de Fátima Souto Maior, Luiz Alcino Monteiro Gueiros, Jair Carneiro Leão & Alessandra Albuquerque Tavares Carvalho

  2. Pharmacy Department, Health Sciences Center, Universidade Federal de Pernambuco, Recife, Brazil

    Jane Sheila Higino

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  1. Ingrid Carla Guedes da Silva Lima
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Lima, I.C.G., de Fátima Souto Maior, L., Gueiros, L.A.M. et al. Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis. Clin Oral Invest 25, 4115–4124 (2021). https://doi.org/10.1007/s00784-020-03743-1

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  • DOI: https://doi.org/10.1007/s00784-020-03743-1

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