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Are recent available blended collagen-calcium phosphate better than collagen alone or crystalline calcium phosphate? Radiotextural analysis of a 1-year clinical trial

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Abstract

Objectives

The purpose of this study is to compare bone regeneration properties of recently available collagen-calcium phosphate (C-CP) blend as bone substitute (BS) material in oral surgery with calcium phosphate (CP) as well as collagen material (Collagen). Is C-CP better than the classic loose CP, or is it at least equally effective in the jawbone regeneration with the superiority of a coherent consistency?

Materials and methods

This study included 102 patients during 12-month follow-up. All patients underwent the following surgical procedures: sinus lift (52patients) and tooth extraction (50patients). Patients were divided into 3 groups which are as follows: experimental group with C-CP, CP and pure Collagen as control groups. Texture analysis was performed in intra-oral radiographs. Analyses were performed in the MaZda 4.6 software. Average 2444-pixel ROIs were established in the image of BS materials and normal trabecular bone for texture comparison to evaluate the jawbone regeneration process. Four features were calculated and investigated.

Results

Texture analyses revealed that all 4 features described the healing process well. Reference textural value of feature SumOfSqrs < 102.37 was soft tissue, DifEntr < 1.1 was not the bone, Entr < 2.62 was not a bone and LngREmph > 1.8 was soft tissue. For 12 months, bone regeneration was proved by 3 of 4 investigated features. Only Entr indicated to CP remnants in the ROI (p < 0.05).

Conclusions

This study proves that blended collagen-calcium phosphate as a BS material can bring satisfactory and predictable outcomes in jawbone regeneration.

Clinical relevance

Clinicians can choose a satisfactory and predictable material for bone regeneration treatment.

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Acknowledgements

The authors thank Medif the for Collagen-CP sample delivery (www.medif.com)

Funding

This research was funded by the Medical University, grant number 503/5-061-02/503-51-001-18, 503/5-061-02/503-51-001-17, 503/5-061-02/503-51-002-18.

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Authors and Affiliations

  1. Department of Maxillofacial Surgery, Medical University in Lodz, Pl. Hallera 1, 90-647, Łódź, Poland

    Tomasz Wach & Marcin Kozakiewicz

Authors
  1. Tomasz Wach
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  2. Marcin Kozakiewicz
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Correspondence to Tomasz Wach.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the University Ethical Committee RNN/485/11/KB. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Wach, T., Kozakiewicz, M. Are recent available blended collagen-calcium phosphate better than collagen alone or crystalline calcium phosphate? Radiotextural analysis of a 1-year clinical trial. Clin Oral Invest 25, 3711–3718 (2021). https://doi.org/10.1007/s00784-020-03697-4

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  • DOI: https://doi.org/10.1007/s00784-020-03697-4

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