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The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis

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Abstract

Objective

To evaluate the effectiveness of microwave disinfection in treating Candida-associated denture stomatitis (CADS).

Materials and methods

The PubMed/MEDLINE, Embase, and Scopus databases were searched for reports on randomized clinical trials (RCTs) published in English until May 2020 (PROSPERO CRD42020192062) that evaluated the treatment of CADS by using microwave disinfection. The main outcomes were the improvement of clinical signs and/or the decrease in the residual yeast present on the dentures and palatal mucosa. The mean differences, standard deviations, risk ratio, and 95% confidence interval were calculated by using the random-effects model. Heterogeneity was assessed by using Cochran’s Q test and I2 values. The level of significance was set at α = 0.05.

Results

Five RCTs with 245 participants were included. The descriptive investigations demonstrated that microwave disinfection was as effective (p > 0.05) as 0.2% chlorhexidine, 0.02% sodium hypochlorite, and topical nystatin (100.000 IU/mL), and was superior to topical miconazole in treating CADS. The metaanalysis did not show a statistical difference between microwave disinfection and nystatin (100.000 IU/mL) treatment in terms of mycological counts, cure, and recurrence rates (p > 0.05).

Conclusion

Microwave disinfection showed comparable results with those of conventional therapies for treating CADS. In addition, treatment with 650 W for 3 min once a week for 14 days had better cost-effect results, indicating both the prevention and treatment of CADS.

Clinical relevance

Our findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality.

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Author information

Authors and Affiliations

  1. Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9-75, Bauru, SP, 17012-901, Brazil

    Rodrigo Moreira Bringel da Costa, Rodrigo Lorenzi Poluha, Giancarlo De la Torre Canales, Paulo Cesar Rodrigues Conti, Karin Hermana Neppelenbroek & Vinicius Carvalho Porto

  2. Department of Health Sciences, School of Dentistry, Centro Universitário Sagrado Coração – UNISAGRADO, Irmã Arminda St., 10-50, Bauru, SP, 17011-160, Brazil

    Joel Ferreira Santiago Junior

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  1. Rodrigo Moreira Bringel da Costa
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  2. Rodrigo Lorenzi Poluha
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  3. Giancarlo De la Torre Canales
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  7. Vinicius Carvalho Porto
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Contributions

Conceptualization: Vinicius Carvalho Porto; Methodology: Joel Ferreira Santiago Junior; Literature search and data analysis: Rodrigo Moreira Bringel da Costa, Rodrigo Lorenzi Poluha, and Giancarlo de La Torre Canales; Meta-analysis: Joel Ferreira Santiago Junior; Writing—original draft preparation: Rodrigo Moreira Bringel da Costa; Writing—review and editing: all authors; Supervision: Vinicius Carvalho Porto, Karin Hermana Neppelenbroek, Joel Ferreira Santiago Junior, and Paulo Cesar Rodrigues Conti.

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Correspondence to Rodrigo Moreira Bringel da Costa.

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da Costa, R.M.B., Poluha, R.L., De la Torre Canales, G. et al. The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis. Clin Oral Invest 24, 3821–3832 (2020). https://doi.org/10.1007/s00784-020-03599-5

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