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Effect of calcium hydroxide mixed with lidocaine hydrochloride on postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis: a preliminary randomized controlled prospective clinical trial

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Abstract

Objectives

To investigate the effect of calcium hydroxide mixed with lidocaine HCl on postoperative spontaneous pain.

Materials and methods

Sixty patients having irreversible pulpitis and symptomatic apical periodontitis with a preoperative spontaneous pain and percussion pain which was more than 50 on a visual analogue scale (100 mm VAS) were included in this study. After the preparation of the root canals, the patients were randomly distributed into two groups according to the calcium hydroxide vehicle, control group (mixed with saline) and calcium hydroxide mixed with lidocaine HCl (n = 30). Postoperative spontaneous pain scores were recorded by a VAS every day for a week. Data were analysed using one-way analysis of variance, chi-squared test and Mann-Whitney U tests (p = 0.05).

Results

The calcium hydroxide mixed with lidocaine HCl group resulted in significantly less pain compared with the calcium hydroxide mixed with saline group during days 1 to 4 (p < 0.05). There were no significant differences between the groups in terms of postoperative percussion pain levels (p > 0.05).

Conclusion

Within the limitations of this study, it can be concluded that the calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.

Clinical relevance

The calcium hydroxide mixed with lidocaine HCl can be beneficial in reducing postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis.

Clinical registration number

TCTR20181121003

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Authors and Affiliations

  1. Department of Endodontics, Faculty of Dentistry, Health Sciences University, İstanbul, Turkey

    Hakan Arslan

  2. Department of Endodontics, Faculty of Dentistry, Bursa Uludağ University, 16059, Bursa, Turkey

    Ezgi Doğanay Yıldız

  3. Department of Endodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey

    Hüseyin Sinan Topçuoğlu

  4. Private Practice, Dental Clinic, İstanbul, Turkey

    Ebru Tepecik

  5. Çorlu Oral and Dental Health Hospital, Tekirdağ, Turkey

    Gizem Taş

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  1. Hakan Arslan
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  2. Ezgi Doğanay Yıldız
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Correspondence to Ezgi Doğanay Yıldız.

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The authors declare that they have no conflict of interest.

Ethical approval

This two-armed parallel clinical study was approved by the Research Ethics Committee of the Faculty of Dentistry, Ataturk University, Erzurum, Turkey (2018/517).

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Informed consent was obtained from all individual participants included in the study.

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Arslan, H., Doğanay Yıldız, E., Topçuoğlu, H.S. et al. Effect of calcium hydroxide mixed with lidocaine hydrochloride on postoperative pain in teeth with irreversible pulpitis and symptomatic apical periodontitis: a preliminary randomized controlled prospective clinical trial. Clin Oral Invest 25, 203–210 (2021). https://doi.org/10.1007/s00784-020-03354-w

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