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Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

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Abstract

Objectives

To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs.

Materials and methods

Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage surgery was performed after 14 weeks. Experimental peri-implantitis was initiated 3 weeks later by ligature placement around the healing caps thus facilitating plaque accumulation and inducing inflammation and destruction of peri-implant tissues. Ligature removal and open flap debridement were performed 11 weeks later. The CBC values were compared with baseline after each procedure. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure.

Results

Following experimental peri-implantitis, statistically significant (p < 0.05) increases were noted for white blood cells—WBC (9.62 ± 4.34 vs. 6.48 ± 1.34 cells per microliter of blood × 1000), hemoglobin—Hb (15.25 ± 0.94 vs. 13.52 ± 1.46, grams per deciliter), red blood cells—RBC (7.26 ± 0.79 vs. 5.9 ± 0.61 cells per microliter of blood × 1000), mean corpuscular hemoglobin—MCH (23.64 ± 0.96 vs. 23.16 ± 0.83 picograms/cell), platelets—PLT (349.86 ± 51.05 vs. 277.57 ± 66 cells per microliter of blood × 1000), and mean corpuscular hemoglobin concentration—MCHC (35.83 ± 0.27 vs. 31.04 ± 0.48 grams per deciliter). A statistically significant (p < 0.05) decrease in values was noted only for after ligature removal and open flap debridement. Mean corpuscular volume—MCV values were significantly lower (65.99 ± 2.31 vs. 74.65 ± 2.85 femtoliter) following 1st ligature. Values returned to baseline after open flap debridement.

Conclusions

Within its limits, the present data suggest that experimentally induced peri-implantitis affects CBC values. Following surgical treatment, CBC values returned to normal.

Clinical relevance

This is the first study suggesting possible relationships between peri-implantitis and CBC values. Future studies, confirming such correlation, may provide an insight into the importance of peri-implant maintenance and treatment to minimize supporting tissues disease and reduce systemic effects.

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Authors and Affiliations

  1. Department of Periodontology and Oral Implantology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel

    Liat Chaushu & Haim Tal

  2. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland

    Anton Sculean

  3. Laparoscopy Unit, Jesús Usón Minimally Invasive Surgery Centre, Caceres, Spain

    Blanca Fernández-Tomé

  4. Department of Oral and Maxillofacial Surgery, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel

    Gavriel Chaushu

  5. Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel

    Gavriel Chaushu

Authors
  1. Liat Chaushu
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  2. Haim Tal
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  3. Anton Sculean
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  4. Blanca Fernández-Tomé
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  5. Gavriel Chaushu
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Corresponding author

Correspondence to Liat Chaushu.

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Conflict of interest

Dr. Liat Chaushu is the founder of Implant B, Nazareth, Israel; Prof. Gavriel Chaushu and Prof. Haim Tal are on the scientific advisory board for Implant B, Nazareth, Israel; Dr. Blanca Fernández-Tomé and Prof. Anton Sculean report no conflicts of interest related to this study.

Ethical approval

Approval number—20160927-3. The study procedures were reviewed and approved by the Ethical Committee of Animal Experimentation of Jesus Usón Minimally Invasive Surgery Center (JUMISC) of Caceres, Spain, and authorized by the competent administration of the board of Extremadura, Spain, considering that the study is in accordance with the established in RD 53/2013 of February 1, 2013 (Directive 2010/63/EU of the European Parliament and of the Council of September 22, 2010).

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Not required. Animal study.

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Chaushu, L., Tal, H., Sculean, A. et al. Peri-implant disease affects systemic complete blood count values—an experimental in vivo study. Clin Oral Invest 24, 4531–4539 (2020). https://doi.org/10.1007/s00784-020-03318-0

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  • DOI: https://doi.org/10.1007/s00784-020-03318-0

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