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Antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trial

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Abstract

Objectives

The aim of this study was to compare the antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries (S-ECC).

Materials and methods

The study was conducted in 92 children with S-ECC. Patients who completed dental treatment under general anaesthesia were included in the study. Patients were divided randomly into four groups: 5% sodium fluoride (SF) control group (n = 23), 5% SF with tricalcium phosphate (TCP) (n = 23), 5% SF with xylitol-coated calcium and phosphate (CXP) (n = 23) and 5% SF with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (n = 23). Saliva mutans streptococci (MS) and lactobacilli (LB) levels were evaluated by taking saliva samples at baseline (T0), 1 month (T1) and 3 months (T2) after treatment.

Results

All groups showed a significant decrease in MS and LB levels at T1 (P < 0.05) except the CXP group. Only the TCP group exhibited significantly decrease MS and LB levels indicating less than 105 CFU at both T1 and T2 compared with the other groups (P < 0.05).

Conclusion

Fluoride varnish with TCP provided significantly more reduction in MS and LB levels than other fluoride varnishes.

Clinical relevance

Fluoride varnish with TCP had a significant antibacterial effect against cariogenic bacteria until the end of the third month. Long lasting antibacterial effect provides additional advantage for reducing bacteria levels in children.

Clinical Trials registration number

NCT03625310

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Funding

This study was funded by the Kırıkkale University Scientific Research Projects Coordination Unit (project number 2015/032).

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Authors and Affiliations

  1. Faculty of Dentistry, Department of Paediatric Dentistry, Kırıkkale University, Kırıkkale, Turkey

    Merve Erkmen Almaz & Aylin Akbay Oba

Authors
  1. Merve Erkmen Almaz
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  2. Aylin Akbay Oba
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Contributions

M.E.A. and A.A.O. conceived the ideas; M.E.A collected the data; M.E.A analysed the data; M.E.A. and A.A.O. led the writing.

Corresponding author

Correspondence to Merve Erkmen Almaz.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Erkmen Almaz, M., Akbay Oba, A. Antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trial. Clin Oral Invest 24, 2129–2136 (2020). https://doi.org/10.1007/s00784-020-03300-w

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  • DOI: https://doi.org/10.1007/s00784-020-03300-w

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