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Depression and anxiety levels in patients with temporomandibular disorders: comparison with the general population

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Abstract

Objectives

The objective of this study was to compare levels of depression and anxiety of a group of patients with orofacial pain attributed to a temporomandibular disorder (TMD) to the general population.

Materials and methods

Diagnosis of orofacial pain attributed to a TMD was given according the DC/TMD classification system. PHQ-9 and GAD-7 questionnaires were used to respectively screen for depression and anxiety. Scores of these two questionnaires in the study group were compared to the scores of two large population samples representing normative data in the general population.

Results

Two hundred forty-three patients (191 females and 52 males) were included in the study. Both Kolmogorov-Smirnov and chi-square testing showed statistically significant higher scores (p ≤ 0.05) for both PHQ-9 and GAD-7 in the study group in comparison with the general population and PHQ-9 and GAD-7 scores were strongly correlated.

Conclusions

The results of this study indicate that screening for depression and anxiety should be considered in the diagnosis of patients with orofacial pain attributed to a TMD.

Clinical relevance

PHQ-9 and GAD-7 could be used to assist clinicians, without specific training in mental health, to screen for potential signs of existing comorbidity of depression or anxiety disorders in patients with orofacial pain attributed to TMD.

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References

  1. Prevalence of TMJD and Its Signs and Symptoms. National Institute of Dental and Craniofacial Research. https://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/FacialPain/. Accessed 19/10/2017

  2. Shetty A, James L, Nagaraj T, Abraham M (2015) Epidemiology of orofacial pain: a retrospective study. J Adv Clin Res Insights 2(1):12–15. https://doi.org/10.15713/ins.jcri.34

    Article  Google Scholar 

  3. Visscher CM, Ligthart L, Schuller AA, Lobbezoo F, de Jongh A, van Houtem CM, Boomsma DI (2015) Comorbid disorders and sociodemographic variables in temporomandibular pain in the general Dutch population. J Oral Facial Pain Headache 29(1):51–59. https://doi.org/10.11607/ofph.1324

    Article  PubMed  Google Scholar 

  4. Türp JC, Schmutzer G, Brähler E, Hauser W (2016) Prevalence of self-reported jaw pain in Germany: two cross-sectional surveys of the general German population. Clin Oral Investig 20(8):1895–1901. https://doi.org/10.1007/s00784-015-1661-7

    Article  PubMed  Google Scholar 

  5. Drangsholt M, LeResche L (1999) Temporomandibular disorder pain. In: Crombie I, Croft P, Linton SJ, LeResche L, Von Korff M (eds) Epidemiology of pain: a report of the Task Force on Epidemiology of the International Association for the Study of Pain. IASP Press, Seattle, pp 203–233

    Google Scholar 

  6. Lipton J, Ship J, Larach-Robinson D (1993) Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 124(10):115–121. https://doi.org/10.14219/jada.archive.1993.0200

    Article  PubMed  Google Scholar 

  7. Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, Max MB, Goldman D, Maixner W (2007) Influence of psychological factors on risk of temporomandibular disorders. J Dent Res 86(11):1120–1125. https://doi.org/10.1177/154405910708601119

    Article  PubMed  Google Scholar 

  8. Fillingim RB, Ohrbach R, Greenspan JD, Knott C, Diatchenko L, Dubner R, Bair E, Baraian C, Mack N, Slade GD, Maixner W (2013) Psychological factors associated with development of TMD: the OPPERA prospective cohort study. J Pain 14(12 Suppl):T75–T90. https://doi.org/10.1016/j.jpain.2013.06.009

    Article  PubMed  Google Scholar 

  9. Sipila K, Ylostalo PV, Joukamaa M, Knuuttila ML (2006) Comorbidity between facial pain, widespread pain, and depressive symptoms in young adults. J Orofac Pain 20(1):24–30

    PubMed  Google Scholar 

  10. Fricton JR, Olsen T (1996) Predictors of outcome for treatment of temporomandibular disorders. J Orofac Pain 10(1):54–65

    PubMed  Google Scholar 

  11. Velly AM, Look JO, Carlson C, Lenton PA, Kang W, Holcroft CA, Fricton JR (2011) The effect of catastrophizing and depression on chronic pain--a prospective cohort study of temporomandibular muscle and joint pain disorders. Pain 152(10):2377–2383. https://doi.org/10.1016/j.pain.2011.07.004

    Article  PubMed  Google Scholar 

  12. Litt MD, Porto FB (2013) Determinants of pain treatment response and nonresponse: identification of TMD patient subgroups. J Pain 14(11):1502–1513. https://doi.org/10.1016/j.jpain.2013.07.017

    Article  PubMed  Google Scholar 

  13. Schiffman E, Look J, Anderson G, Goldberg LJ, Haythornthwaite JA, Hollender L, John MT, Meulen MVD, Murray GM, Nixdorf DR, Pionchon P, Smith B, Visscher CM (2014) Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the international RDC/TMD consortium network and orofacial pain special interest group. J Oral Facial Pain Headache 28(1):6–27. https://doi.org/10.11607/jop.1151

    Article  PubMed  PubMed Central  Google Scholar 

  14. Löwe B, Spitzer RL, Gräfe K, Kroenke K, Quenter A, Zipfel S, Buchholz C, Witte S, Herzog W (2004) Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians’ diagnoses. J Affect Disord 78(2):131–140

    Article  PubMed  Google Scholar 

  15. Spitzer RL, Kroenke K, Williams JB, Lowe B (2006) A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166(10):1092–1097. https://doi.org/10.1001/archinte.166.10.1092

    Article  PubMed  Google Scholar 

  16. Diagnostic Criteria for Temporomandibular Disorders: Assessment Instruments. Version 15May2016. Accessed 18/05/2018

  17. Spitzer RL, Kroenke K, Williams JB (1999) Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary care evaluation of mental disorders. Patient Health Questionnaire. JAMA 282(18):1737–1744

    Article  PubMed  Google Scholar 

  18. Ohrbach R, Gonzalez Y, List T, Michelotti A, Schiffman EL Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Clinical Examination Protocol: Version 02June2013. www.rdc-tmdinternational.org Accessed 18/05/2018

  19. Diagnostic Criteria for Temporomandibular Disorders: Assessment Instruments. Version 15May2016. [Diagnostische Criteria voor Temporomandibulaire Disfunctie: Onderzoeksinstrumenten: DutchVersion 14June2016]. Knibbe W, Loyen NA, Meulen MJ van der & Lobbezoo F, Trans. www.rdc-tmdinternational.org Accessed 18/05/2018

  20. Vilanova LS, Garcia RC, List T, Alstergren P (2015) Diagnostic criteria for temporomandibular disorders: self-instruction or formal training and calibration? J Headache Pain 16:505. https://doi.org/10.1186/s10194-015-0505-9

    Article  PubMed  Google Scholar 

  21. Ohrbach R, editor. Diagnostic Criteria for Temporomandibular Disorders: Assessment Instruments. Version 15May2016. [Diagnostische Criteria voor Temporomandibulaire Disfunctie: Onderzoeksinstrumenten: DutchVersion 14June2016]. Knibbe W, Loyen NA, Meulen MJ van der & Lobbezoo F, Trans.www.rdc-tmdinternational.org Accessed 18/05/2018

  22. Spitzer RL, Williams JB, Kroenke K phqscreeners: PHQ-9. https://www.phqscreeners.com/sites/g/files/g10049256/f/201412/PHQ9_Dutch%20for%20Belgium.pdf. Accessed 18/05/2018

  23. Spitzer RL, Williams JB, Kroenke K phqscreeners: GAD-7. https://www.phqscreeners.com/sites/g/files/g10049256/f/201412/GAD7_Dutch%20for%20Belgium.pdf. Accessed 18/05/2018

  24. Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16(9):606–613

    Article  PubMed  PubMed Central  Google Scholar 

  25. Wittkampf KA, Naeije L, Schene AH, Huyser J, van Weert HC (2007) Diagnostic accuracy of the mood module of the Patient Health Questionnaire: a systematic review. Gen Hosp Psychiatry 29(5):388–395. https://doi.org/10.1016/j.genhosppsych.2007.06.004

    Article  PubMed  Google Scholar 

  26. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Association, Arlington

    Book  Google Scholar 

  27. Moriarty AS, Gilbody S, McMillan D, Manea L (2015) Screening and case finding for major depressive disorder using the Patient Health Questionnaire (PHQ-9): a meta-analysis. Gen Hosp Psychiatry 37(6):567–576. https://doi.org/10.1016/j.genhosppsych.2015.06.012

    Article  PubMed  Google Scholar 

  28. Manea L, Gilbody S, McMillan D (2015) A diagnostic meta-analysis of the Patient Health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depression. Gen Hosp Psychiatry 37(1):67–75. https://doi.org/10.1016/j.genhosppsych.2014.09.009

    Article  PubMed  Google Scholar 

  29. Gilbody S, Richards D, Brealey S, Hewitt C (2007) Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis. J Gen Intern Med 22(11):1596–1602. https://doi.org/10.1007/s11606-007-0333-y

    Article  PubMed  PubMed Central  Google Scholar 

  30. Manea L, Gilbody S, McMillan D (2012) Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. CMAJ 184(3):E191–E196. https://doi.org/10.1503/cmaj.110829

    Article  PubMed  PubMed Central  Google Scholar 

  31. Ohrbach R, Knibbe W DiagnosticCriteria forTemporomandibularDisorders: Scoring Manual for Self-Report Instruments.Version29May2016.www.rdc-tmdinternational.org Accessed 18/05/2018

  32. Plummer F, Manea L, Trepel D, McMillan D (2016) Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis. Gen Hosp Psychiatry 39:24–31. https://doi.org/10.1016/j.genhosppsych.2015.11.005

    Article  PubMed  Google Scholar 

  33. Kocalevent R-D, Hinz A, Brähler E (2013) Standardization of the depression screener Patient Health Questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry 35(5):551–555. https://doi.org/10.1016/j.genhosppsych.2013.04.006

    Article  PubMed  Google Scholar 

  34. Löwe B, Decker O, Müller S, Brähler E, Schellberg D, Herzog W, Herzberg PY (2008) Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population. Med Care 46(3):266–274. https://doi.org/10.1097/MLR.0b013e318160d093

    Article  PubMed  Google Scholar 

  35. Coolican H (2014) Research methods and statistics in psychology. In: Research methods and statistics in psychology, 6th edn. Psychology press, New York

    Google Scholar 

  36. Fields A (2009) Discovering statistics using SPSS, 3rd edn. Sage Publication Inc., Londen

    Google Scholar 

  37. Kindler S, Samietz S, Houshmand M, Grabe HJ, Bernhardt O, Biffar R, Kocher T, Meyer G, Volzke H, Metelmann HR, Schwahn C (2012) Depressive and anxiety symptoms as risk factors for temporomandibular joint pain: a prospective cohort study in the general population. J Pain 13(12):1188–1197. https://doi.org/10.1016/j.jpain.2012.09.004

    Article  PubMed  Google Scholar 

  38. Dunn KM, Jordan KP, Mancl L, Drangsholt MT, Le Resche L (2011) Trajectories of pain in adolescents: a prospective cohort study. Pain 152(1):66–73. https://doi.org/10.1016/j.pain.2010.09.006

    Article  PubMed  PubMed Central  Google Scholar 

  39. Ohrbach R, Dworkin SF (1998) Five-year outcomes in TMD: relationship of changes in pain to changes in physical and psychological variables. Pain 74(2–3):315–326

    Article  PubMed  Google Scholar 

  40. Wright AR, Gatchel RJ, Wildenstein L, Riggs R, Buschang P, Ellis E 3rd (2004) Biopsychosocial differences between high-risk and low-risk patients with acute TMD-related pain. J Am Dent Assoc (1939) 135(4):474–483

    Article  PubMed  Google Scholar 

  41. Turner JA, Mancl L, Aaron LA (2006) Short- and long-term efficacy of brief cognitive-behavioral therapy for patients with chronic temporomandibular disorder pain: a randomized, controlled trial. Pain 121(3):181–194. https://doi.org/10.1016/j.pain.2005.11.017

    Article  PubMed  Google Scholar 

  42. Gardea MA, Gatchel RJ, Mishra KD (2001) Long-term efficacy of biobehavioral treatment of temporomandibular disorders. J Behav Med 24(4):341–359

    Article  PubMed  Google Scholar 

  43. Dworkin SF, Turner JA, Mancl L, Wilson L, Massoth D, Huggins KH, LeResche L, Truelove E (2002) A randomized clinical trial of a tailored comprehensive care treatment program for temporomandibular disorders. J Orofac Pain 16(4):259–276

    PubMed  Google Scholar 

  44. Dworkin SF, Huggins KH, Wilson L, Mancl L, Turner J, Massoth D, LeResche L, Truelove E (2002) A randomized clinical trial using research diagnostic criteria for temporomandibular disorders-axis II to target clinic cases for a tailored self-care TMD treatment program. J Orofac Pain 16(1):48–63

    PubMed  Google Scholar 

  45. Bair E, Ohrbach R, Fillingim RB, Greenspan JD, Dubner R, Diatchenko L, Helgeson E, Knott C, Maixner W, Slade GD (2013) Multivariable modeling of phenotypic risk factors for first-onset TMD: the OPPERA prospective cohort study. J Pain 14(12 Suppl):T102–T115. https://doi.org/10.1016/j.jpain.2013.09.003

    Article  PubMed  PubMed Central  Google Scholar 

  46. Beck AT (2005) The current state of cognitive therapy: a 40-year retrospective. Arch Gen Psychiatry 62(9):953–959. https://doi.org/10.1001/archpsyc.62.9.953

    Article  PubMed  Google Scholar 

  47. Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, Kerns RD, Stucki G, Allen RR, Bellamy N, Carr DB, Chandler J, Cowan P, Dionne R, Galer BS, Hertz S, Jadad AR, Kramer LD, Manning DC, Martin S, McCormick CG, McDermott MP, McGrath P, Quessy S, Rappaport BA, Robbins W, Robinson JP, Rothman M, Royal MA, Simon L, Stauffer JW, Stein W, Tollett J, Wernicke J, Witter J (2005) Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 113(1–2):9–19. https://doi.org/10.1016/j.pain.2004.09.012

    Article  PubMed  Google Scholar 

  48. Bakker IM, Terluin B, van Marwijk HWJ, van Mechelen W, Stalman WAB (2009) Test-retest reliability of the PRIME-MD: limitations in diagnosing mental disorders in primary care. Eur J Pub Health 19(3):303–307. https://doi.org/10.1093/eurpub/ckn149

    Article  Google Scholar 

  49. Maixner W, Diatchenko L, Dubner R, Fillingim RB, Greenspan JD, Knott C, Ohrbach R, Weir B, Slade GD (2011) Orofacial pain prospective evaluation and risk assessment study – the OPPERA study. J Pain 12(11 Suppl):T4–T4. https://doi.org/10.1016/j.jpain.2011.08.002

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

The work was supported by the Department of Oral Health Sciences, Faculty of Medicine and Health Sciences, Ghent University.

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Correspondence to Louis Simoen.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Simoen, L., Van den Berghe, L., Jacquet, W. et al. Depression and anxiety levels in patients with temporomandibular disorders: comparison with the general population. Clin Oral Invest 24, 3939–3945 (2020). https://doi.org/10.1007/s00784-020-03260-1

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