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Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma

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Abstract

Objectives

The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis.

Materials and methods

The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed.

Results

The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181–1.843; p < 0.01), poorer ECOG-PS (2–4 vs 0–1; HR, 1.560; 95%CI, 1.14–2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405–0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575–1.034; p = 0.081).

Conclusion

The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.

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Abbreviations

OSCC:

Oral squamous cell carcinoma

QOL:

Quality of life

GA:

Geriatric assessment

ECOG-PS:

Eastern Cooperative Oncology Group Performance status

CCI:

Charlson comorbidity index

NCCN:

National Comprehensive Cancer Network

SR:

Self-reliance survival

PS:

Performance status

OS:

Overall survival

CSS:

Cancer-specific survival

HR:

Hazard ratio

95%CI:

95% confidence interval

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Author information

Authors and Affiliations

  1. Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan

    Shin-ichi Yamada, Masao Hashidume & Hiroshi Kurita

  2. Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Takumi Hasegawa & Masaya Akashi

  3. Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Kohei Okuyama

  4. Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan

    Nobuhiro Yamakawa & Tadaaki Kirita

  5. The 1st Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Osaka, Japan

    Masaya Okura

  6. Department of Clinical Oral Oncology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Souichi Yanamoto & Masahiro Umeda

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  1. Shin-ichi Yamada
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  2. Takumi Hasegawa
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Contributions

Conception and design of the study: YS and KH

Analysis and interpretation of data: YS and KH

Collection and assembly of data: YS, HT, OK, YN, OM, HM, YS, AM, KT, and UM

Drafting of the article: YS

Critical revision of the article for important intellectual content: YS

Final approval of the article: KH

Corresponding author

Correspondence to Shin-ichi Yamada.

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The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Ethics Committee of the Shinshu University School of Medicine (No. 3391).

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Cite this article

Yamada, Si., Hasegawa, T., Okuyama, K. et al. Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma. Clin Oral Invest 24, 1953–1961 (2020). https://doi.org/10.1007/s00784-019-03056-y

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  • DOI: https://doi.org/10.1007/s00784-019-03056-y

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