Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study



To evaluate salivary adiponectin and adenosine deaminase (ADA) in women suffering from Sjögren’s syndrome (SS).


Salivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19). A clinical history was made for each patient, patients were examined clinically, and xerostomia inventory (XI) was performed.


Salivary adiponectin corrected by total protein was higher in patients with SS than in healthy individuals (P < 0.05) or patients with non-SS sicca (P < 0.01) and correlated with XI (r = 0.555; P < 0.05). Salivary ADA was higher in patients with SS and non-SS sicca compared to controls (P < 0.05 in both cases).


The results of the present study indicate that adiponectin and ADA are increased in the saliva of patients with SS.

Clinical relevance

Salivary adiponectin corrected by total protein can be a potential biomarker of SS.

Trial registration


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AT was financially supported by the Program “Juan de la Cierva Incorporacion” of “Ministerio de Economia y Competitividad,” Spain, through a post-doctoral grant.

Author information




AT, PLJ, FT, and SMS designed the study; PLJ, FP, and CZ collected the samples; AT, FT, and SMS analysed the samples; AT, PLJ, FT, and SMS analysed the data; AT, PLJ, FT, and SMS drafted, revised, and approved the manuscript.

Corresponding author

Correspondence to Asta Tvarijonaviciute.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Tvarijonaviciute, A., Zamora, C., Martinez-Subiela, S. et al. Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren’s syndrome: a pilot study. Clin Oral Invest 23, 1407–1414 (2019).

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  • Adiponectin
  • Adenosine deaminase
  • Biomarker
  • Clinical signs
  • Xerostomia
  • Saliva