The correlation between the quality of oral hygiene and oral HPV infection in adults: a prospective cross-sectional study
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Various risk factors for oral human papillomavirus (HPV) infections have been described, including tobacco smoking and sexual behavior. However, less is known about the influence of oral health on such infections. The present study aimed to determine a possible association between the quality of oral hygiene and the presence of oral HPV.
In a prospective analysis, the approximal plaque index (API), the gingival bleeding index (GBI), and the lifetime number of extracted teeth was determined in 187 patients. Additionally, the presence of oral low-risk and/or high-risk HPV was investigated by brush smear testing in all participants.
Seventy-four patients had an API < 20%, 84 participants showed an API of 20–40%, and in 29 cases, an API > 40% was recorded. Ninety-six patients presented a GBI < 20%, 75 had a GBI of 20–40%, and 16 showed a GBI > 40%. One hundred four patients had experienced one to three extractions, and 36 had lost more than three teeth. Thirty-nine participants had a positive oral HPV testing (27 high-risk HPV, 26 low-risk HPV, 14 low- and high-risk HPV). A higher API respectively GBI and a greater number of extracted teeth were significantly correlated with the presence of high-risk HPV. The presence of low-risk HPV was significantly higher in patients with API > 40% and GBI > 40% (OR 7.89). Similar results were found regarding the number of extracted teeth.
The present analysis confirms a relationship between the quality of oral hygiene, determined by objective markers. Thus, improvement of oral health may reduce the incidence of oral HPV infection.
The present article investigates the relationship between oral hygiene and the presence of oral HPV. As a significant correlation between these two factors could be recorded, improvement of oral hygiene may reduce actively the incidence of oral HPV. Thereby, good oral hygiene may contribute oral cancer prevention.
KeywordsOral HPV Oral hygiene Oral cancer Plaque index Gingival index Tooth loss
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in the study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. The study has been approved by the Ethical Committee of the Medical University of Innsbruck (nr. AN5192 328/4.8).
Informed consent was obtained from all individual participants included in the study.
- 2.Jitani AK, Raphael V, Mishra J, Shunyu NB, Khonglah Y, Medhi J (2015) Analysis of human papilloma virus 16/18 DNA and its correlation with p16 expression in oral cavity squamous cell carcinoma in north-eastern India: a chromogenic in-situ hybridization based study. J Clin Diagn Res 9:EC04–EC07. https://doi.org/10.7860/JCDR/2015/13022.6285 PubMedPubMedCentralGoogle Scholar
- 4.Dalla Torre D, Burtscher D, Edlinger M, Solder E, Widschwendter A, Rasse M, Puelacher W (2015) Comparison of the prevalence of human papilloma virus infection in histopathologically confirmed premalignant oral lesions and healthy oral mucosa by brush smear detection. Oral Surg Oral Med Oral Pathol Oral Radiol 119:333–339. https://doi.org/10.1016/j.oooo.2014.11.013 CrossRefPubMedGoogle Scholar
- 6.D'Souza G, Cullen K, Bowie J, Thorpe R, Fakhry C (2014) Differences in oral sexual behaviors by gender, age, and race explain observed differences in prevalence of oral human papillomavirus infection. PLoS One 9:e86023. https://doi.org/10.1371/journal.pone.0086023 CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Bui TC, Tran LT, Markham CM, Huynh TT, Tran LT, Pham VT, Tran QM, Hoang NH, Hwang LY, Sturgis EM (2015) Self-reported oral health, oral hygiene, and oral HPV infection in at-risk women in Ho Chi Minh City, Vietnam. Oral Surg Oral Med Oral Pathol Oral Radiol 120:34–42. https://doi.org/10.1016/j.oooo.2015.04.004 CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Sun CX, Bennett N, Tran P, Tang KD, Lim Y, Frazer I, Samaranayake L, Punyadeera C (2017) A pilot study into the association between oral health status and human papillomavirus-16 infection. Diagnostics 7(1):11. https://doi.org/10.3390/diagnostics7010011
- 18.Kofler B, Borena W, Manzl C, Dudas J, Wegscheider AS, Jansen-Durr P, Schartinger V, Riechelmann H (2017) Sensitivity of tumor surface brushings to detect human papilloma virus DNA in head and neck cancer. Oral Oncol 67:103–108. https://doi.org/10.1016/j.oraloncology.2017.02.013 CrossRefPubMedGoogle Scholar
- 20.Chaudhary AK, Pandya S, Mehrotra R, Bharti AC, Singh M, Singh M (2010) Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma. Virol J 7:253. https://doi.org/10.1186/1743-422X-7-253 CrossRefPubMedPubMedCentralGoogle Scholar
- 21.Termine N, Giovannelli L, Matranga D, Caleca MP, Bellavia C, Perino A, Campisi G (2011) Oral human papillomavirus infection in women with cervical HPV infection: new data from an Italian cohort and a metanalysis of the literature. Oral Oncol 47:244–250. https://doi.org/10.1016/j.oraloncology.2011.02.011 CrossRefPubMedGoogle Scholar
- 22.Gipson BJ, Robbins HA, Fakhry C, D'Souza G (2018) Sensitivity and specificity of oral HPV detection for HPV-positive head and neck cancer. Oral Oncol 77:52–56. https://doi.org/10.1016/j.oraloncology.2017.12.008 CrossRefPubMedGoogle Scholar