Clinical Oral Investigations

, Volume 22, Issue 6, pp 2187–2197 | Cite as

Effect of flapless ridge preservation with two different alloplastic materials in sockets with buccal dehiscence defects—volumetric and linear changes

  • Nadja Naenni
  • Vitor Sapata
  • Stefan P. Bienz
  • Minas Leventis
  • Ronald E. Jung
  • Christoph H. F. Hämmerle
  • Daniel S. Thoma
Original Article



To test whether or not one out of two alloplastic materials used for ridge preservation (RP) is superior to the other in terms of volumetric and linear ridge changes over time.

Materials and methods

In 16 adult beagle dogs, the distal roots of P3 and P4 were extracted and 50% of the buccal bone plate removed. Ridge preservation was performed randomly using two different alloplastic bone grafting substitutes (poly lactic-co-glycolic acid (PLGA) coated biphasic calcium phosphate particles consisting of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (ß-TCP=test 1), (a biphasic calcium phosphate consisting 60% HA and 40% ß-TCP=test 2) and a resorbable collagen membrane or a control group (sham). Sacrifice was performed at three time-points (4, 8, 16 weeks later). Impressions were taken before extraction, after RP, and at sacrifice, allowing for assessment of volumetric changes. A multi-way ANOVA was computed, and partial Type-II F tests were performed.


Both ridge preservation procedures minimized the volume loss compared to spontaneous healing. The median buccal volume changes between pre-extraction and sacrifice were − 1.76 mm (Q1 = − 2.56; Q3 = − 1.42) for test 1, − 1.62 mm (Q1 = − 2.06; Q3 = − 1.38) for test 2, and − 2.42 mm (Q1 = − 2.63; Q3 = − 2.03) for control. The mean ridge width measurements did not show statistically significant differences between test 1 (− 2.51 mm; Q1 = − 3.25; Q3 = − 1.70) and test 2 (− 2.04 mm; Q1 = − 3.82; Q3 = − 1.81) (p = 0.813), but between test and control (− 3.85 mm; Q1 = − 5.02; Q3 = − 3.27) (p = 0.003).


Both RP techniques were successful in maintaining the buccal contour from pre-extraction to sacrifice to a similar extent and more favorable compared to spontaneous healing.

Clinical relevance

Alloplastic materials can successfully be used for RP procedures.


Ridge preservation Volume stability Alveolar ridge augmentation (MeSH



The authors would like to acknowledge Dr. M. Mayer, for his support in the statistical analysis of the data and the animal care team at NAMSA, Lyon, France, for assistance during surgery. The support and expertise of Dr. Lorenz Uebersax, Sunstar Suisse SA, Etoy, Switzerland, is highly appreciated. This study was funded by Sunstar Suisse SA, Etoy, Switzerland and the Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.


The work was supported by Sunstar Suisse SA, Etoy, Switzerland and the Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Nadja Naenni
    • 1
  • Vitor Sapata
    • 1
  • Stefan P. Bienz
    • 1
  • Minas Leventis
    • 2
  • Ronald E. Jung
    • 1
  • Christoph H. F. Hämmerle
    • 1
  • Daniel S. Thoma
    • 1
  1. 1.Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental MedicineUniversity of ZurichZurichSwitzerland
  2. 2.Laboratory of Experimental Surgery and Surgical Research N. S. Christeas, Medical SchoolUniversity of AthensAthensGreece

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