Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial
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The present randomized double-blind clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.
Methods and materials
One hundred and five subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: (1) nano-hydroxyapatite 2% gel toothpaste fluoride free; (2) fluoride gel toothpaste; (3) placebo. Groups 1, 2, and 3 were instructed to treat their teeth for 10 min twice a day with the provided toothpaste gel. The participant’s dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analogue scale was used.
Significant lower values of cold air sensitivity and tactile sensitivity (p < 0.05) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significant (p < 0.05) lower values of sensitivity were reported for group 1 compared to those for groups 2 and 3 at 2 and 4 weeks, respectively. The VAS scores were significantly lower (p < 0.05) in the test group at 2 and 4 weeks compared to those at baseline and in the control groups.
The application of nano-hydroxyapatite in gel toothpaste fluoride free is an effective desensitizing agent providing relief from symptoms after 2 and 4 weeks.
KeywordsDentine hypersensitivity Nano-hydroxyapatite Fluoride Desensitizing agents
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The authors declare that no financial relationships exist regarding any of the products involved in this study.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The protocol and informed consent forms were approved by the ethics committee of the University of Sassari (n° DH 2362CE).
Informed consent was obtained from all individual participants included in the study.
- 20.Roveri, N, Foresti E, Lelli M, Lesci, IG. (2009) Recent advancements in preventing teeth health hazard: the daily use of hydroxyapatite instead of fluoride. Recent Patents on Biomedical Engineering 197–215. doi: 10.2174/1874764710902030197
- 22.Yuan P, Shen X, Liu J, Hou Y, Zhu M, Huang J, Xu P (2012) Effects of dentifrice containing hydroxyapatite on dentinal tubule occlusion and aqueous hexavalent chromium cations sorption: a preliminary study. PLoS One 7:e45283. doi: 10.1371/journal.pone.0045283 CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Orsini G, Procaccini M, Manzoli L, Giuliodori F, Lorenzini A, Putignano A (2010) A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. J Clin Periodontol 37:510–517. doi: 10.1111/j.1600-051X.2010.01558.x CrossRefPubMedGoogle Scholar
- 33.Mason S, Hughes N, Sufi F, Bannon L, Maggio B, North M, Holt J (2010) A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentine hypersensitivity. J Clin Dent 21:42–48PubMedGoogle Scholar
- 34.Hughes N, Mason S, Jeffery P, Welton H, Tobin M, O’Shea C, Browne M (2010) A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. J Clin Dent 21:49–55PubMedGoogle Scholar