Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial

  • M. Vano
  • G. Derchi
  • A. Barone
  • R. Pinna
  • P. Usai
  • U Covani
Original Article

Abstract

Objectives

The present randomized double-blind clinical trial aimed to compare the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.

Methods and materials

One hundred and five subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: (1) nano-hydroxyapatite 2% gel toothpaste fluoride free; (2) fluoride gel toothpaste; (3) placebo. Groups 1, 2, and 3 were instructed to treat their teeth for 10 min twice a day with the provided toothpaste gel. The participant’s dentin hypersensitivity was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analogue scale was used.

Results

Significant lower values of cold air sensitivity and tactile sensitivity (p < 0.05) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significant (p < 0.05) lower values of sensitivity were reported for group 1 compared to those for groups 2 and 3 at 2 and 4 weeks, respectively. The VAS scores were significantly lower (p < 0.05) in the test group at 2 and 4 weeks compared to those at baseline and in the control groups.

Conclusion

The application of nano-hydroxyapatite in gel toothpaste fluoride free is an effective desensitizing agent providing relief from symptoms after 2 and 4 weeks.

Keywords

Dentine hypersensitivity Nano-hydroxyapatite Fluoride Desensitizing agents 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Dept of Surgical Pathology, Medicine, Molecular and Critical AreaUniversity of PisaPisaItaly
  2. 2.Tuscan Stomatologic InstituteViareggioItaly
  3. 3.Dept of Oral SurgeryUniversity of GenevaGenèveSwitzerland
  4. 4.Dept of Biomedical SciencesUniversity of SassariSassari (SS)Italy

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