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Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse

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Abstract

Objectives

The purpose of this clinical study was to determine the antibacterial and antiplaque efficacy of a recently introduced octenidine-containing mouthrinse (Octenidol®) in comparison with established antiseptic mouthrinses.

Materials and methods

In a 4-day plaque-regrowth study employing a four-replicate cross-over design, a 0.1 % octenidine mouthrinse (Octenidol®/OCT-MR) was compared with a 0.12 % chlorhexidine mouthrinse (Paroex®/CHX-MR), an essential oil mouthrinse (Listerine®/EO-MR), and a placebo mouthrinse/P-MR. Plaque regrowth was assessed with a modified Quigley-Hein plaque index. The antibacterial effect was assessed by taking bacterial counts from the tooth surface and oral mucosa after professional tooth cleaning and after first rinsing with the allocated mouthrinse on days 1 and 5. Sixteen volunteers suspended tooth cleaning and rinsed twice daily with the allocated mouthrinse for 4 days.

Results

All tested antiseptic mouthrinses were significantly more effective than the placebo mouthrinse in inhibiting plaque, but no significant differences were observed between OCT-MR and CHX-MR, OCT-MR and EO-MR, and CHX-MR and EO-MR. After 4 days, comparable bacterial count levels were found on both the tooth surface and mucosa applying OCT-MR and CHX-MR, which were significantly lower than that of EO-MR and P-MR.

Conclusion

Octenidol® and Paroex® showed comparable antibacterial and antiplaque efficacy in the human oral cavity.

Clinical Relevance

The recently introduced octenidine-containing mouthrinse Octenidol® may become a suitable alternative to 0.12 % chlorhexidine-containing mouthrinses such as Paroex®.

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Acknowledgments

Our gratitude goes to the statistician of the University Medicine Greifswald, Dr. P. Kolyschkow, for his help.

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Authors and Affiliations

  1. Department of Restorative Dentistry, Periodontology, Endodontology, Preventive and Pediatric Dentistry, Dental School, University Medicine Greifswald, Walther-Rathenau-Str. 42a, 17475, Greifswald, Germany

    Alexander Welk & Maral Zahedani

  2. Private Practice, Schwerin, Germany

    Carolin Beyer

  3. Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany

    Axel Kramer & Gerald Müller

Authors
  1. Alexander Welk
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  2. Maral Zahedani
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  3. Carolin Beyer
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  4. Axel Kramer
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  5. Gerald Müller
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Corresponding author

Correspondence to Alexander Welk.

Ethics declarations

The study was approved by the Ethics Committee of the University of Greifswald (BB 99/12).

Conflict of interest

The authors declare that they have no competing interests.

Source of funding

The study was supported by the University Medicine Greifswald and partially by Schülke & Mayr GmbH—Germany.

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Welk, A., Zahedani, M., Beyer, C. et al. Antibacterial and antiplaque efficacy of a commercially available octenidine-containing mouthrinse. Clin Oral Invest 20, 1469–1476 (2016). https://doi.org/10.1007/s00784-015-1643-9

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  • DOI: https://doi.org/10.1007/s00784-015-1643-9

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