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Inhibition of de novo plaque growth by a new 0.03 % chlorhexidine mouth rinse formulation applying a non-brushing model: a randomized, double blind clinical trial

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Abstract

Objectives

The aim of this study was to investigate the plaque inhibitory effect of a new 0.03 % chlorhexidine digluconate (CHX) and 0.05 % cetylpyridinium chloride (CPC) mouthrinse formulation and to explore patients’ experience and side effects after its use.

Materials and methods

This short-term, randomized, double blind, parallel, clinical trial enrolled 150 periodontally healthy patients. These volunteers were randomly allocated to one of following mouthrinse groups (n = 50/group): 0.12 % CHX + 0.05 % CPC (Perio-Aid® Treatment alcohol-free), 0.03 % CHX + 0.05 % CPC new test formulation or to the placebo group. Clinical parameters (plaque, gingival, and stain indexes) and microbiological samples were taken at baseline, before supragingival cleaning, and after 4 days of undisturbed plaque growth, rinsing twice/day with one of the mouthrinses.

Results

Plaque reduction was similar for the 0.12 % CHX (−0.52 ± 0.55) and 0.03 % CHX (−0.47 ± 0.49) groups. Both showed significant reductions in plaque accumulation compared to the placebo (p < 0.001). The new formulation had less of a negative impact on taste perception when compared to the 0.12 % CHX solution. The new CHX mouthrinse was also able to control bacterial loads and reduce some periodontopathogens.

Conclusions

This study indicated that the new 0.03 % CHX + 0.05 % CPC formulation exerted clinical efficacy similar to that achieved by an already-marketed 0.12 % CHX + 0.05 % CPC mouthrinse, but with slightly fewer side effects.

Clinical relevance

Lower CHX mouthrinse formulations could be effective in the inhibition of plaque regrowth with reduced unpleasant subjective side effects.

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Acknowledgments

The authors wish to thank Vanessa Blanc, Rubén León, and Ann Bangle for their help during the study design and their suggestions during manuscript preparation.

Disclosure form

This study was funded by the Universitat Internacional de Catalunya and partially supported by a grant from Dentaid (Cerdanyola del Valles, Barcelona, Spain). Dentaid provided us with the RTF vials and conducted microbiological analysis in the Dentaid Research Center. The authors report no conflicts of interest related to this study. There is no financial relationship between any author and the commercial firm.

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Authors and Affiliations

  1. Department of Periodontology, Hospital General de Catalunya, Universitat Internacional de Catalunya, C/ Josep Trueta s/n, C.P. 08195, Sant Cugat del Vallès, Barcelona, Spain

    Carolina Mor-Reinoso, Andres Pascual & Jose Nart

  2. Departments of Oral Health Sciences and Periodontology, Katholieke Universiteit Leuven, University Hospitals & Dentistry Leuven, Leuven, Belgium

    Marc Quirynen

Authors
  1. Carolina Mor-Reinoso
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  2. Andres Pascual
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  3. Jose Nart
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  4. Marc Quirynen
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Corresponding author

Correspondence to Andres Pascual.

Additional information

ClinicalTrials.gov Identifier: NCT02194023

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Mor-Reinoso, C., Pascual, A., Nart, J. et al. Inhibition of de novo plaque growth by a new 0.03 % chlorhexidine mouth rinse formulation applying a non-brushing model: a randomized, double blind clinical trial. Clin Oral Invest 20, 1459–1467 (2016). https://doi.org/10.1007/s00784-015-1625-y

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  • DOI: https://doi.org/10.1007/s00784-015-1625-y

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