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Elevated insulin resistance in patients with recurrent aphthous stomatitis

Clinical Oral Investigations volume 19, pages 1193–1197 (2015)Cite this article

Abstract

Objectives

The role of glucose metabolism disorders in periodontal diseases including recurrent aphthous stomatitis (RAS) is currently attracting attention. The aim of this study is to investigate insulin resistance (IR) in patients with RAS in otherwise healthy individuals.

Materials and methods

The study enrolled 81 patients with RAS and 61 healthy control subjects. Blood glucose, insulin, C-peptide, hemoglobin A1c, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and HOMA-IR were measured in each individual.

Results

Forty-two of the RAS group were in the active, and 39 of the RAS group were in the passive stage. The levels of c-peptide, insulin, and HOMA-IR were remarkably higher in the RAS group (p = 0.015; p < 0.0001; p < 0.0001, respectively) than the control group. The levels of HbA1c, glucose (p = 0,045), TC (p = 0,008), HDL cholesterol (p = 0,002), and HOMA-IR (p = 0.022) were significantly higher in patients with RAS in the active stage.

Conclusion

The study revealed an elevated IR in patients with RAS that was not previously shown. IR was more prominent when the patients were in the active stage that elevated inflammatory cytokines may induce IR by interfering with insulin signaling. Further studies, investigating the interplay between RAS, inflammation, and IR are needed.

Clinical relevance

Patients who admitted the hospital with RAS might be screened for prediabetes.

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Disclosure statement

The authors have nothing to disclose.

Funding

This article received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Department of Dermatology, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey

    Z. Takci

  2. Department of Dermatology, Faculty of Medicine, Göztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey

    A. S. Karadag

  3. Ankara Kecioren Research and Training Hospital, Department of Internal Medicine, Division of Endocrinology and Metabolism,, Ankara, Turkey

    D. T. Ertugrul

  4. Department of Dermatology, Yuzuncu yil University, Faculty of Medicine, Van, Turkey

    S. G. Bilgili

Authors
  1. Z. Takci
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  2. A. S. Karadag
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  3. D. T. Ertugrul
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  4. S. G. Bilgili
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Corresponding author

Correspondence to Z. Takci.

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Takci, Z., Karadag, A.S., Ertugrul, D.T. et al. Elevated insulin resistance in patients with recurrent aphthous stomatitis. Clin Oral Invest 19, 1193–1197 (2015). https://doi.org/10.1007/s00784-014-1339-6

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  • DOI: https://doi.org/10.1007/s00784-014-1339-6

Keywords

  • Insulin resistance
  • Recurrent aphthous stomatitis
  • Periodontal disease
  • Inflammation