Clinical Oral Investigations

, Volume 18, Issue 8, pp 1881–1892 | Cite as

Long-term periodontal tissue outcome in regenerated infrabony and furcation defects: a systematic review

  • Eduardo Aleixo Figueira
  • Angélica Oliveira de Assis
  • Sheyla Christinne Lira Montenegro
  • Diego Moura Soares
  • Anna Angélica Araújo Barros
  • Euler Maciel Dantas
  • Bruno César de Vasconcelos GurgelEmail author



This study aimed to systematically evaluate the long-term results of periodontal tissues in regenerated infrabony and furcation defects.

Material and methods

A search of the Medline database was performed (1960 to 2012), complimented by an additional hand search. For inclusion in the review, clinical trials had to include the long-term evaluation of infrabony and furcation defects submitted to periodontal regeneration for up to 3 years of follow-up. Changes in clinical attachment level (CAL) from pre-surgery, at the first post-surgical, and final evaluations were used to analyze the effects of regenerative treatments over time.


A total of 866 articles were found using the descriptors employed. Of these, 216 papers were selected for abstract reading by two evaluators. One hundred and eighty-nine were excluded for not fulfilling the eligibility criteria. Twenty-seven papers were selected for the analysis of the full texts, and 13 were excluded. Two studies were included after a manual search. Finally, 16 papers were selected for the present review.


Regenerative techniques for the treatment of infrabony and furcation defects resulted in improved CAL during long-term follow-up periods, even when attachment losses occurred during this period. This improvement should be carefully evaluated with regard to its clinical relevance for dental longevity.

Clinical relevance

The improvement in clinical attachment level achieved by regenerative techniques with biomaterials demonstrated satisfactory results over the long-term. However, regenerative techniques still present different success rates with regard to gain in clinical attachment level.


Periodontal regeneration Furcation lesion Osseous defects Systematic review 


Conflict of interest

The authors declare that they have no conflicts of interests.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Eduardo Aleixo Figueira
    • 1
  • Angélica Oliveira de Assis
    • 1
  • Sheyla Christinne Lira Montenegro
    • 1
  • Diego Moura Soares
    • 1
  • Anna Angélica Araújo Barros
    • 1
  • Euler Maciel Dantas
    • 1
  • Bruno César de Vasconcelos Gurgel
    • 1
    Email author
  1. 1.Federal University of Rio Grande do NorteNatalBrazil

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