Clinical Oral Investigations

, Volume 18, Issue 8, pp 1963–1968 | Cite as

Effect of nonsurgical periodontal therapy (with or without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes: a short-term longitudinal randomized case–control study

  • Fawad JavedEmail author
  • Hameeda Bashir Ahmed
  • Abid Mehmood
  • Crawford Bain
  • Georgios E. Romanos
Original Article



The aim of the present short-term longitudinal randomized case–control study was to assess the effect of nonsurgical periodontal therapy (NSPT) (with and without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes.

Material and methods

Sixty-six patients with prediabetes and periodontal disease were included. Characteristics of the study cohort (age, gender, socioeconomic status [SES] education status, duration of prediabetes, and type of treatment adopted for prediabetes management) were recorded. Patients were randomly divided into two groups (33 patients/group). In group 1, scaling and root planing (SRP) was performed, and in group-2, patients underwent SRP and oral doxycycline (100 mg) administration once daily for 15 days. In each group, the following parameters were investigated at baseline and after 3 months: (a) fasting blood glucose level (FBGL), (b) hemoglobin A1c (HbA1c), and (c) periodontal parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and clinical attachment loss [AL]). Statistical analysis was performed using Student’s t test.


There was no significant difference in age, gender, SES, education status, and duration and treatment of prediabetes among individuals in groups 1 and 2. Three months post-NSPT, FBGL and HbA1c were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. Three months post-NSPT, PI (P < 0.05), BOP (P < 0.05), and PD (P < 0.05) were significantly reduced among patients in group 1 (P < 0.05) and group 2 (P < 0.05) compared to baseline. There was no difference in clinical AL between the groups after 3 months of NSPT.


NSPT (with and without oral doxycycline delivery) reduces hyperglycemia and periodontal inflammation in patients with prediabetes.


Dental scaling Hemoglobin A1c Hyperglycemia Nonsurgical periodontal debridement Prediabetic state Root planing 



The authors would like to thank the College of Dentistry Research Center and Deanship of Scientific Research at King Saud University, Saudi Arabia for funding this research project (project # FR 0071).

Conflict of interest

The authors report no conflict of interest related to the present study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Fawad Javed
    • 1
    Email author
  • Hameeda Bashir Ahmed
    • 2
  • Abid Mehmood
    • 3
  • Crawford Bain
    • 4
  • Georgios E. Romanos
    • 5
  1. 1.Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Lab., College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of DentistryAl-Farabi Dental CollegeRiyadhSaudi Arabia
  3. 3.Department of DentistryJinnah HospitalKarachiPakistan
  4. 4.Department of PeriodontologyDubai School of Dental MedicineDubaiUnited Arab Emirates
  5. 5.Department of Clinical Affairs, School of Dental MedicineStony Brook UniversityStony BrookUSA

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