Clinical Oral Investigations

, Volume 18, Issue 8, pp 1919–1923 | Cite as

Oxidative stress and recurrent aphthous stomatitis

  • Jose BaganEmail author
  • Guillermo Saez
  • Carmen Tormos
  • Carmen Gavalda
  • Jose M. Sanchis
  • Leticia Bagan
  • Crispian Scully
Original Article



This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.

Material and methods

Oxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.


The mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (p < 0.01). There was a nonsignificant tendency toward higher MDA and GSSG levels in patients with major RAS compared with minor RAS. On comparing the serum findings in the nine RAS patients in the presence and absence of lesions, the presence of ulceration was associated with even higher MDA and GSSG levels and lower GSH concentrations (p < 0.05)


Oxidative stress was detected in our RAS patients.


Recurrent aphthous stomatitis Oxidative stress Malondialdehyde (MDA) Reduced glutathione (GSH) Oxidized glutathione (GSSG) 


Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jose Bagan
    • 1
    Email author
  • Guillermo Saez
    • 2
  • Carmen Tormos
    • 2
  • Carmen Gavalda
    • 1
  • Jose M. Sanchis
    • 1
  • Leticia Bagan
    • 1
  • Crispian Scully
    • 3
  1. 1.Oral Medicine Department, Service of Stomatology and Maxillofacial Surgery, University General HospitalUniversity of ValenciaValenciaSpain
  2. 2.Department of Biochemistry, School of MedicineUniversity of ValenciaValenciaSpain
  3. 3.University College LondonLondonUK

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