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Oxidative stress and recurrent aphthous stomatitis

Clinical Oral Investigations volume 18, pages 1919–1923 (2014)Cite this article

Abstract

Objectives

This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.

Material and methods

Oxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.

Results

The mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (p < 0.01). There was a nonsignificant tendency toward higher MDA and GSSG levels in patients with major RAS compared with minor RAS. On comparing the serum findings in the nine RAS patients in the presence and absence of lesions, the presence of ulceration was associated with even higher MDA and GSSG levels and lower GSH concentrations (p < 0.05)

Conclusions

Oxidative stress was detected in our RAS patients.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Affiliations

  1. Oral Medicine Department, Service of Stomatology and Maxillofacial Surgery, University General Hospital, University of Valencia, Avda/Tres Cruces s/n, 46014, Valencia, Spain

    Jose Bagan, Carmen Gavalda, Jose M. Sanchis & Leticia Bagan

  2. Department of Biochemistry, School of Medicine, University of Valencia, Valencia, Spain

    Guillermo Saez & Carmen Tormos

  3. University College London, London, UK

    Crispian Scully

Authors
  1. Jose Bagan
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  2. Guillermo Saez
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  3. Carmen Tormos
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  4. Carmen Gavalda
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  5. Jose M. Sanchis
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  6. Leticia Bagan
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  7. Crispian Scully
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Corresponding author

Correspondence to Jose Bagan.

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Bagan, J., Saez, G., Tormos, C. et al. Oxidative stress and recurrent aphthous stomatitis. Clin Oral Invest 18, 1919–1923 (2014). https://doi.org/10.1007/s00784-013-1181-2

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  • DOI: https://doi.org/10.1007/s00784-013-1181-2

Keywords

  • Recurrent aphthous stomatitis
  • Oxidative stress
  • Malondialdehyde (MDA)
  • Reduced glutathione (GSH)
  • Oxidized glutathione (GSSG)