Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial
- 1.2k Downloads
The aim of this study is to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in combination with coronally advanced flap (CAF) in the treatment of localized gingival recessions.
Materials and methods
Twenty-two patients with localized gingival recession defects (Miller I, II) participated in this split-mouth trial. Forty-four defects received either CAF + PRF (test) or CAF with subepithelial connective tissue graft (SCTG) (control). Gingival recession depth (RD), gingival recession width (RW), keratinized tissue width (KTW), recession area (RA), probing depth (PD), clinical attachment level (CAL) and gingival thickness (GT) were evaluated at baseline and 6 months. RD, RW, RA and KTW were calculated on standardized photographs with a computer image analysis program.
Percentage of root coverage in test group was 92.7 % and in control group was 94.2 % (p > 0.05). Percentage of complete root coverage of the test and control groups was 72.7 and 77.3 %, respectively (p > 0.05). KTW and GT were increased in both groups from baseline to 6 months (p < 0.001), but there was no statistically significant difference between treatment groups (p > 0.05).
Within the limits of the present study, it can be concluded that localized gingival recessions could be successfully treated with CAF + PRF as well as CAF + SCTG. The digital measuring method provided high accuracy and precision in the evaluation of treatment outcomes after both surgical procedures.
PRF might be suggested as an alternative to SCTG for the treatment of localized gingival recessions.
Key WordsGingival recession Fibrin Connective tissue Plastic surgery Microsurgery Case–control studies
This study was supported by a grant from Ege University Research Projects Grant 2010-Dental-002. The authors thank Prof. Dr. Mehmet Orman, Department of Biostatistics and Medical Informatics, School of Medicine, Ege University, İzmir, who performed statistical analysis.
Conflict of interest statement
The authors report no conflicts of interest related to this study.
- 1.Grupe HE, Warren RF (1956) Repair of gingival defects by a sliding flap operation. J Periodontol 27:290–295Google Scholar
- 6.Roccuzzo M, Bunino M, Needleman I, Sanz M (2001) Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review. J Clin Periodontol 29(suppl 3):57–63Google Scholar
- 10.Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D (2009) Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 80:244–252PubMedCrossRefGoogle Scholar
- 12.Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B et al (2012) Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restor Dent 32:41–50Google Scholar
- 16.Cairo F, Pagliaro U & Nieri M (2008) Treatment of gingival recession with coronally advanced flap procedures: a systematic review. J Clin Periodontol 35 (Suppl. 8):136–162.Google Scholar
- 19.Toffler M, Toscano N, Holtzclaw D, DelCorso M, Ehrenfest D (2009) Introducing Choukroun’s platelet rich fibrin to the reconstructive surgery milieu. J Implant Adv Clin Dent 6:21–32Google Scholar
- 20.Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte MP et al (2009) In vitro effects of Choukroun’s PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:341–352PubMedCrossRefGoogle Scholar
- 22.Zhang Y, Tangl S, Huber CD, Lin Y, Qiu L et al (2012) Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. J Craniomaxillofac Surg 40:321–328PubMedCrossRefGoogle Scholar
- 26.Miller PD Jr (1985) A classification of marginal tissue recession. Int J Periodontics Restor Dent 5:8–13Google Scholar
- 29.Choukroun J, Ada F, Schoeffler C, Vervelle A (2001) An opportunity in perio-implantology: the PRF (in French). Implantodontie 42:55–62Google Scholar
- 41.Padma R, Shilpa A, Kumar PA, Nagasri M, Kuma C, Sreedhar A (2013) A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller’s class-I and II recession defects. J Indian Soc Periodontol 17:631–636PubMedCrossRefPubMedCentralGoogle Scholar
- 49.Harris RJ, Miller R, Miller LH, Harris C (2005) Complications with surgical procedures utilizing connective tissue grafts: a follow-up of 500 consecutively treated cases. Int J Periodontics Restor Dent 25:449–459Google Scholar
- 52.Harris RJ, Harris AW (1994) The coronally positioned pedicle graft with inlaid margins: a predictable method of obtaining root coverage of shallow defects. Int J Periodontics Restor Dent 14:228–241Google Scholar