Clinical Oral Investigations

, Volume 18, Issue 8, pp 1941–1948 | Cite as

Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial

  • Gülnihal ErenEmail author
  • Gül Atilla
Original Article



The aim of this study is to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in combination with coronally advanced flap (CAF) in the treatment of localized gingival recessions.

Materials and methods

Twenty-two patients with localized gingival recession defects (Miller I, II) participated in this split-mouth trial. Forty-four defects received either CAF + PRF (test) or CAF with subepithelial connective tissue graft (SCTG) (control). Gingival recession depth (RD), gingival recession width (RW), keratinized tissue width (KTW), recession area (RA), probing depth (PD), clinical attachment level (CAL) and gingival thickness (GT) were evaluated at baseline and 6 months. RD, RW, RA and KTW were calculated on standardized photographs with a computer image analysis program.


Percentage of root coverage in test group was 92.7 % and in control group was 94.2 % (p > 0.05). Percentage of complete root coverage of the test and control groups was 72.7 and 77.3 %, respectively (p > 0.05). KTW and GT were increased in both groups from baseline to 6 months (p < 0.001), but there was no statistically significant difference between treatment groups (p > 0.05).


Within the limits of the present study, it can be concluded that localized gingival recessions could be successfully treated with CAF + PRF as well as CAF + SCTG. The digital measuring method provided high accuracy and precision in the evaluation of treatment outcomes after both surgical procedures.

Clinical relevance

PRF might be suggested as an alternative to SCTG for the treatment of localized gingival recessions.

Key Words

Gingival recession Fibrin Connective tissue Plastic surgery Microsurgery Case–control studies 



This study was supported by a grant from Ege University Research Projects Grant 2010-Dental-002. The authors thank Prof. Dr. Mehmet Orman, Department of Biostatistics and Medical Informatics, School of Medicine, Ege University, İzmir, who performed statistical analysis.

Conflict of interest statement

The authors report no conflicts of interest related to this study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Periodontology, School of DentistryEge UniversityBornovaTurkey

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