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Biochemical analysis of the articular disc of the temporomandibular joint with magnetic resonance T2 mapping: a feasibility study

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Abstract

Objectives

Symptoms of temporomandibular joint (TMJ) dysfunction can seriously compromise patients' quality of life. The aim of our study was to use magnetic resonance imaging (MRI) T2 mapping of the articular disc to determine whether T2 mapping of the TMJ disc is feasible in routine clinical imaging and to assess the normal T2 relaxation time distribution within the TMJ.

Methods

Included were ten asymptomatic volunteers without pain, any mouth-opening limitations, or any clicking phenomena. MR imaging was performed on a 3-T MR scanner using a flexible, dedicated, eight-channel multielement coil. T2 mapping was performed in the oblique sagittal plane. The regions of interest (ROIs) for the T2 relaxation time maps of the disc were selected manually.

Results

The mean values for ROIs ranged between 22.4 and 28.8 ms, and the mean for all ROIs was 26.0 ± 5.0 ms. Intraclass correlation (ICC) for interobserver variability was 0.698, and ICC for intraobserver variability was 0.861. There was no statistically significant difference between raters (p = 0.091) or sides (p = 0.810).

Conclusion

The T2 mapping technique enables ultrastructural analysis of the composition of TMJ disc. This biochemical technique is feasible in vivo, as shown in our study, when a high-field (3 T) MR and a dedicated TMJ coil are used.

Clinical relevance

T2 mapping as a biochemical technique, together with morphological MRI, may help to gain more insights into the physiology and into the pathophysiology of the articular disc in the TMJ noninvasively and in vivo.

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Acknowledgments

This study was funded by the Austrian Science Fund FWF grant P23481-B19, Vienna Spots of Excellence of the Vienna Science and Technology Fund (WWTF), Vienna Advanced Imaging Center (VIACLIC FA102A0017), and grant VEGA 2/0013/14 of the Slovak Grant Agency. We would like to thank the volunteers, and we highly appreciate the technical support of Claudia Kronnerwetter. We would like to give a special thanks to Prof. Hanns Plenk from the Institute for Histology and Embryology/Medical University of Vienna and Prof. Monika Egerbacher from the Institute for Anatomy, Histology and Embryology of the University of Veterinary Medicine for their valuable support with the histological evaluation.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Prosthodontics, Bernhard Gottlieb University of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria

    Martina Schmid-Schwap, Margit Bristela, Astrid Skolka & Eva Piehslinger

  2. Department of Orthodontics, Bernhard Gottlieb University of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria

    Elisabeth Pittschieler

  3. High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna/Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Pavol Szomolanyi & Siegfried Trattnig

  4. Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Dubravska cesta 9, 84219, Bratislava, Slovakia

    Pavol Szomolanyi

  5. Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna/Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Michael Weber

  6. Austrian Cluster for Tissue Regeneration, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrase 13, 1200, Vienna, Austria

    Siegfried Trattnig

Authors
  1. Martina Schmid-Schwap
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  2. Margit Bristela
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  3. Elisabeth Pittschieler
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  4. Astrid Skolka
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  5. Pavol Szomolanyi
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  6. Michael Weber
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  7. Eva Piehslinger
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  8. Siegfried Trattnig
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Correspondence to Martina Schmid-Schwap.

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Schmid-Schwap, M., Bristela, M., Pittschieler, E. et al. Biochemical analysis of the articular disc of the temporomandibular joint with magnetic resonance T2 mapping: a feasibility study. Clin Oral Invest 18, 1865–1871 (2014). https://doi.org/10.1007/s00784-013-1154-5

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  • DOI: https://doi.org/10.1007/s00784-013-1154-5

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