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Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: a systematic review

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Abstract

Objectives

To evaluate the effectiveness of natural compounds containing mouthrinse (NCCM) as an adjunct to unsupervised oral hygiene in the management of dental plaque and gingivitis.

Materials and methods

An electronic search for clinical studies of NCCMs was conducted in Medline-PubMed, the Cochrane Central Register of Controlled Trials and EMBASE for a period spanning from the earliest available date in each database up to February 2013. Plaque index, gingival index, and gingival bleeding index were selected as primary outcomes. The methodological quality of the studies was assessed according to the “Levels of Evidence” outlined by the Center of Evidence-Based Medicine, and to the Jadad scale.

Results

The screen yielded 2,236 titles and abstracts that met the inclusion criteria. These identified 11 clinical trials testing 13 different NCCMs, and were used for data extraction. Heterogeneity and the limited number of studies on any individual NCCM precluded a formal meta-analysis. Of the 13 NCCMs tested, eight demonstrated positive results, and few reported any adverse effects or events.

Conclusions

Evidence proving the effectiveness of NCCM as an adjunct to unsupervised oral hygiene for plaque and gingivitis control is still insufficient. However, some natural products (compounds) may have oral health benefits, so further high-quality study is warranted.

Clinical relevance

This review provides an overview of the strength of clinical evidence regarding the effectiveness of natural compounds containing mouthrinses in promoting gingival health.

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Acknowledgments

We declare that this research was not supported by any external grant. The authors have no conflicts of interest to report related to this study

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Authors and Affiliations

  1. Department of Orthodontics, Affiliated Stomatological Hospital of Fujian Medical University, Fujian, China

    Yong Chen

  2. Discipline of Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China

    Ricky WK Wong & Urban Hagg

  3. Discipline of Dental Public Health, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China

    Colman McGrath

  4. Discipline of Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore, Singapore

    C Jayampath Seneviratne

  5. Orthodontics, Prince Philip Dental Hospital, 2/F, Orthodontics, 34 Hospital Road, Hong Kong, China

    Ricky WK Wong

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  1. Yong Chen
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  2. Ricky WK Wong
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  3. Colman McGrath
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  4. Urban Hagg
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  5. C Jayampath Seneviratne
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Corresponding author

Correspondence to Ricky WK Wong.

Appendix

Appendix

Table 7 Overview of the excluded NCCM clinical studies
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Chen, Y., Wong, R.W., McGrath, C. et al. Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: a systematic review. Clin Oral Invest 18, 1–16 (2014). https://doi.org/10.1007/s00784-013-1033-0

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