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Herpes simplex virus reactivation and dental procedures

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Abstract

Objectives

Dental extraction is reported to trigger recurrent herpes labialis (RHL).

Aim

This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1) viral shedding before and 3 days after different dental procedures.

Materials and methods

Oral HSV-1 DNA was measured by real-time PCR before and 3 days after dental procedures of the inferior dentition in 57 immunocompetent patients (mean age 32.4 years) who were selected and divided into four distinct subgroups (dental inspection without anesthesia, n = 19; dental filling under local anesthesia, n = 14; molar extraction under local anesthesia, n = 15; and molar extraction under general anesthesia, n = 9) and compared to 32 healthy controls (mean age 33 years).

Results

None of the patients suffered from RHL at day 3. Oral HSV-1 DNA was detected before and after procedure in 1.7 % (1/57) and 5.3 % (3/57), respectively [dental inspection without anesthesia, 5.3 % (1/19); molar extraction under local anesthesia, 6.7 % (1/15); and molar extraction under general anesthesia, 11 % (1/9)]. None of the controls presented RHL or detectable oral HSV-1 DNA. There was no statistically significant difference between the study groups and controls.

Conclusion

Molar extraction increases the risk of oral HSV-1 shedding but not of RHL. Procedure-related nerve damage probably accounts for HSV reactivation.

Clinical relevance

Antiviral prophylaxis for RHL is not routinely recommended for dental procedures, regardless of a prior history of RHL.

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Conflict of interest

The authors declare that they have no conflicts of interest

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Authors and Affiliations

  1. Department of Dermatology, University Medical Center Liège, 4000, Liège, Belgium

    L. El Hayderi & A. F. Nikkels

  2. Department of Pathology, University Medical Center Liège, Liège, Belgium

    P. Delvenne

  3. Department of Dentistry, University Medical Center Liège, Liège, Belgium

    E. Rompen

  4. Department of Clinical Biology, CHR Citadelle, Liège, Belgium

    J. M. Senterre

Authors
  1. L. El Hayderi
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  2. P. Delvenne
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  3. E. Rompen
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  4. J. M. Senterre
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  5. A. F. Nikkels
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Corresponding author

Correspondence to A. F. Nikkels.

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El Hayderi, L., Delvenne, P., Rompen, E. et al. Herpes simplex virus reactivation and dental procedures. Clin Oral Invest 17, 1961–1964 (2013). https://doi.org/10.1007/s00784-013-0986-3

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  • DOI: https://doi.org/10.1007/s00784-013-0986-3

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