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Concentrations of amoxicillin and clindamycin in teeth following a single dose of oral medication

Abstract

Objectives

The main purpose of this study is the detection of amoxicillin and clindamycin concentrations in teeth.

Materials and methods

Eleven patients received 2 g of amoxicillin, and 11 patients received 600 mg of clindamycin in a single dose of oral medication at least 60 min prior to tooth extraction due to systemic diseases. The concentrations were determined in crowns and roots separately using liquid chromatography–tandem mass spectrometry (LC-MS-MS).

Results

Amoxicillin (13 samples) and clindamycin (12 samples) were detected in the samples of the root and crown preparations of the extracted teeth. The mean concentration of amoxicillin was 0.502 μg/g in the roots and 0.171 μg/g in the crowns. The mean concentration of clindamycin was 0.270 μg/g in the roots and 0.064 μg/g in the crowns.

Conclusions

A single dose of oral amoxicillin and clindamycin leads to concentrations of both antibiotics in teeth which exceed the minimal inhibition concentration of some oral bacteria.

Clinical relevance

The proof of antibacterial activity in dental hard tissue after oral single-dose application is new. The antimicrobial effect of amoxicillin and clindamycin concentrations in roots of teeth may be of clinical relevance to bacterial reinfection from dentinal tubules.

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Fig. 1

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Acknowledgments

We gratefully acknowledge Heike Jahnke for the skillful technical assistance.

Ethical standard

The study was performed in agreement with the Ethics Commission of the Medical Faculty of Freiburg University, Germany: Antrags-Nr. EK-Freiburg 55/09.

Conflict of interest

The authors declare that they have no conflict of interest.

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Correspondence to Klaus Pelz.

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Schüssl, Y., Pelz, K., Kempf, J. et al. Concentrations of amoxicillin and clindamycin in teeth following a single dose of oral medication. Clin Oral Invest 18, 35–40 (2014). https://doi.org/10.1007/s00784-013-0958-7

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Keywords

  • Amoxicillin
  • Clindamycin
  • Tissue concentration
  • Teeth
  • Single oral dose
  • Liquid chromatography–tandem mass spectrometry (LC-MS-MS)