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Clinical use of an epinephrine-reduced (1/400,000) articaine solution in short-time dental routine treatments—a multicenter study

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Abstract

The addition of epinephrine in dental local anaesthesia results in a longer and deeper anaesthesia under almost ischemic conditions. For short-time dental treatments, epinephrine-reduced anaesthetics may offer shorter and more individual anaesthesia with reduced potential side effects. The aim of this study was a clinical evaluation of anaesthetic potency and adverse effects of an epinephrine-reduced articaine formulation in dental patients undergoing short-time routine treatment. In a prospective clinical, not interventional, study between January 2008 and February 2009, 908 patients undergoing short-time dental treatment in five medical centers were anaesthetized with 4% articaine 1:400,000 epinephrine (Ubistesin™, 3M/ESPE, Seefeld, Germany). Efficacy and safety in clinical use were evaluated. A follow-up after 1 day was conducted by telephone survey. A mean amount of 1.3-ml anaesthetic solution was needed to achieve a complete or sufficient anaesthesia in 97% (n = 876) of cases. A second injection had to be done in 3.7% (n = 34) before and in 11.9% (n = 108) during treatment. Here, the second injection had to be applied after a mean of 48.6 min. The mean duration of soft tissue anaesthesia after infiltration was 146.6 min, after nerve block 187.7 min. The painful treatment took a mean of 50.2 min and the total treatment time summed up to 68.8 min. In 1.7% cases (n = 15), unwanted side effects were observed. The results indicate that a lower concentration of epinephrine in combination with the 4% articaine solution leads to a high success rate of efficacy. The clinical use of a 4% articaine 1:400,000 epinephrine solution can be stated as safe and effective in short dental routine treatments. Reconsiderations concerning limitations of indication or additional contraindications are not necessary.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Policlinic for Oral Surgery, University Medical Centre of the Johannes Gutenberg University Mainz, Augustusplatz 2, 55131, Mainz, Germany

    Monika Daubländer

  2. Department of Oral and Maxillofacial Surgery, University Medical Centre Mainz, Mainz, Germany

    Peer W. Kämmerer

  3. Please check captured corresponding author and corresponding e-mail if appropriate.Department of Operative Dentistry, University Medical Centre Mainz, Mainz, Germany

    Brita Willershausen

  4. Department of Prosthodontics, University of Heidelberg, Heidelberg, Germany

    Michael Leckel

  5. Department of Prosthodontics, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

    Hans-Christoph Lauer

  6. Wiesbaden, Germany

    Siegmar Buff

  7. Neuhofen, Germany

    Benita Rösl

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  1. Monika Daubländer
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  4. Michael Leckel
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Correspondence to Monika Daubländer.

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Daubländer, M., Kämmerer, P.W., Willershausen, B. et al. Clinical use of an epinephrine-reduced (1/400,000) articaine solution in short-time dental routine treatments—a multicenter study. Clin Oral Invest 16, 1289–1295 (2012). https://doi.org/10.1007/s00784-011-0608-x

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  • DOI: https://doi.org/10.1007/s00784-011-0608-x

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