Abstract
This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair.
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Acknowledgements
These investigations were carried out with the support of a CNRS/INSERM grant (Ingénierie tissulaire 2000), INSERM grant Cellules souches adultes 2003 and Fondation de l'Avenir ETS-407). This article is dedicated to more than 25 years of friendship between the first author and Prof. Dr. Gottfried Schmalz.
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Goldberg, M., Lacerda-Pinheiro, S., Priam, F. et al. Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration. Clin Oral Invest 12, 109–112 (2008). https://doi.org/10.1007/s00784-007-0172-6
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DOI: https://doi.org/10.1007/s00784-007-0172-6