Abstract
Previous work showed that a single application of 40% chlorhexidine varnish, EC40®, reduced plaque acidogenicity upon sucrose challenge during less than 3 weeks. It was questioned whether lactic acid production could be reduced significantly longer when the treatment was intensified. Therefore, the effects of three consecutive EC40® applications on plaque acidogenicity were evaluated. Nine subjects who participated in the previous study received three full mouth EC40® applications within 1 week. Before the first application and up to 9 weeks after the third application, plaque samples were taken after a 10% sucrose rinse and analyzed for organic acids with capillary electrophoresis. At baseline, the mean provoked lactic acid concentration was 1.64 (±0.69) μmol/mg protein. At the first and seventh day after the third application, there was too little plaque to measure acid concentrations. At 2 weeks after the third application, lactic acid concentrations were significantly reduced (p < 0.05). The acid concentrations 3 weeks after the third application (1.61 (±0.99) μmol/mg protein) did not differ from the values at baseline (paired T test, p > 0.05). We conclude that a triple 40% chlorhexidine varnish treatment did not affect plaque acidogenicity for more than 3 weeks. From comparison with a previous study, we conclude that the triple treatment with EC40® within 1 week was not more effective in reducing plaque acidogenicity than the single one.
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Gerardu, V.A.M., Buijs, M.J., ten Cate, J.M. et al. Effect of an intensified treatment with 40% chlorhexidine varnish on plaque acidogenicity. Clin Oral Invest 11, 77–81 (2007). https://doi.org/10.1007/s00784-006-0079-7
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DOI: https://doi.org/10.1007/s00784-006-0079-7