Skip to main content

Advertisement

SpringerLink
Log in

Comparative investigations on the efficacy of articaine 4% (epinephrine 1:200,000) and articaine 2% (epinephrine 1:200,000) in local infiltration anaesthesia in dentistry—a randomised double-blind study

  • Original Article
  • Published:
Clinical Oral Investigations Aims and scope Submit manuscript

Abstract

A randomised double-blind study investigated 155 patients with tooth extractions in the mandibular and maxillary jaws for a loss of anaesthetic potency when reducing the concentration of the active in articaine solutions. Tests were performed on the preparations of articaine 4% with a 1:200,000 addition of epinephrine (Ultracain D-S) and articaine 2% with a 1:200,000 addition of epinephrine (Ultracain 2%-Suprarenin). Local infiltration anaesthesia was the chosen method of anaesthesia. The most noticeable difference observed between the two injection solutions concerned the duration of anaesthesia, which was significantly shortened under the low-dose solution. The 4% articaine solution did not prove superior in local anaesthetic effect. Articaine 2% with epinephrine 1:200,000, therefore, can be considered a suitable local anaesthetic for tooth extractions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Dirnbacher T, Glockmann E, Taubenheim L (2003) Welche anästhesie ist die richtige. Zahnarztl Mitt 23:44–51

    Google Scholar 

  2. Feller K (1990) Pharmakologie der lokalanästhetika. In: Lokalanästhesie-Erkenntnisstand und Perspektive. Aktuelles Wissen Hoechst 7–13

  3. Flanze L (1991) Vergleichende untersuchung zur lokalanästhetischen wirksamkeit einer 2-bzw. 4-prozentigen articain-lösung in der zahnheilkunde. Diss. Frankfurt am Main

  4. Fritzsche C, Päβler L (2000) Ultracain D-S und ultracain 2%-suprarenin-vergleichende untersuchungen zur lokalanästhesie in der zahnärztlichen chirurgie. Quintessenz 51:507–514

    Google Scholar 

  5. Fritzsche C (1999) Vergleichende Untersuchungen mit den lokalanästhetika ultracain D-S und ultracain 2%-suprarenin. Diss. Dresden

  6. Haas DA, Harper DG, Saso MA (1991) Lack of differential effect by ultracaine (Articaine) and citanest (Prilocaine) in infiltration anesthesia. J Can Dent Assoc 57:217–223

    PubMed  Google Scholar 

  7. Isen DA (2000) Articaine: pharmacology and clinical use of a recently approved local anesthetic. Dent Today 19(11):74–77

    Google Scholar 

  8. Jakobs W, Ladwig P, Cichon P, Oertel R, Kirch W (1995) Serum levels of articaine 2% and 4% in children. Anesth Prog 42:113–115

    PubMed  Google Scholar 

  9. Jakobs W, Schmidt J, Leiers C (1991) Ultracain 2% with epinephrine in pediatric dentistry. In: 6th International Dental Congress on Modern Pain Control, Washington, DC, May 1991

  10. Jastak JT, Yagiela JA, Donaldson D (1995) Local anesthesia of the oral cavity. Saunders, Philadelphia, PA

    Google Scholar 

  11. Klammt J (1990) Das Versagen der lokalanästhesie. In: Zahnärztliche Lokalanästhesie heute-Zwei Jahrzehnte Articain. Aktuelles Wissen Hoechst

  12. Knoll-Köhler E (1988) Sicherheit bei der lokalanästhesie II: pharmakologie lokalanästhetischer substanzen. Phillip J 1:33–41

    Google Scholar 

  13. Knoll-Köhler E (1991) Lokalanästhesie in der zahnheilkunde. Zahnarztl Mitt 23:2370–2375

    Google Scholar 

  14. Knoll-Köhler E (1991) Vergleichende untersuchung äquimolarer lösungen von lidocain und articain zur anästhesie. Schweiz Monatsschr Zahnmed 101:1286–1290

    PubMed  Google Scholar 

  15. Lemay H, Albert G, Helie P, Dufour L, Gagnon P, Payant L, Laliberte R (1984) Ultracaine en dentisterie operatoire conventionelle. J Can Dent Assoc 50:703–708

    PubMed  Google Scholar 

  16. Löffler H (1997) Vergleichende Untersuchung der lokalanästhetischen Wirksamkeit und Knochengängigkeit unterschiedlicher Dosen von Articain-bzw. Lidocainlösungen in der Zahnheilkunde. Med Diss. Frankfurt

  17. Minner E (1994) Lokalanästhetische wirksamkeit unterschiedlich konzentrierter articain-lösungen in der zahnheilkunde. Diss. Frankfurt am Main

  18. Mueller WPE, Weiser P, Scholler KL (1991) Pharmakokinetik von articain bei der nervus mandibularis-blockade. Reg Anaesth 14:52–55

    PubMed  Google Scholar 

  19. Oertel R, Rahn R, Kirch W (1997) Clinical pharmacokinetics of articaine. Clin Pharmacokinet 33:417–425

    Article  PubMed  Google Scholar 

  20. Päβler L, von Wickede J (1996) Articain, lidocain, prilocain und vasokonstriktorische zusätze—untersuchungen zur verminderung des anästhesierisikos. Quintessenz 47:669–678

    Google Scholar 

  21. Rahn R (2003) Zahnärztliche lokalanästhesie. Forum-med-Aventis

  22. Rahn R, Hauzeneder W, Flanze L (1991) Wirksamkeit einer zweiprozentigen, adrenalinfreien articain-lösung (Ultracain 2%) zur zahnärztlichen lokalanästhesie. Dtsch Stomatol 41:379–382

    PubMed  Google Scholar 

  23. Rahn R, Hofmann R, Minner E (1994) Lokalanästhetische Wirksamkeit unterschiedlich konzentrierter adrenalinfreier articain-lösungen. Zahnarztl Welt 46:745–782

    Google Scholar 

  24. Sitzmann F, Lindorf HH (1976) Vergleichende experimentelle reizschwellenmessungen der wirkung des lokalanästhetikums ultracain (Carticain). Dtsch Zahnärztl Z 31:128–130

    PubMed  Google Scholar 

  25. Szabo G, Divinyi T (1987) Vergleichende untersuchungen mit ultracain D-S und ultracain D-S forte. Stomatol DDR 37:301–304

    PubMed  Google Scholar 

  26. Vähätalo K, Antila H, Lehtinen R (1993) Articaine and lidocaine for maxillary infiltration anesthesia. Anesth Prog 40:114–116

    PubMed  Google Scholar 

  27. Winther JE, Nathalang B (1972) Effectivity of a new local analgesic HOE 40045. Scand J Dent Res 80:272–278

    PubMed  Google Scholar 

  28. Winther JE, Patirupanasura B (1974) Evaluation of carticaine—a new local analgesic. Int J Oral Surg 3:422–427

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University of Technology, Dresden, Germany

    A. Hintze & L. Paessler

  2. Department of Paediatric Dentistry, University of Technology, Fetscherstr. 74, 01309, Dresden, Germany

    A. Hintze

Authors
  1. A. Hintze
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Paessler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Hintze.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hintze, A., Paessler, L. Comparative investigations on the efficacy of articaine 4% (epinephrine 1:200,000) and articaine 2% (epinephrine 1:200,000) in local infiltration anaesthesia in dentistry—a randomised double-blind study. Clin Oral Invest 10, 145–150 (2006). https://doi.org/10.1007/s00784-005-0025-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00784-005-0025-0

Keywords

Search

Navigation