Skip to main content
Log in

Cervical myelopathy caused by bilateral C1–2 dumbbell ganglioneuromas and C2–3 and C3–4 neurofibromas associated with neurofibromatosis type 1

  • Case Report
  • Published:
Journal of Orthopaedic Science

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  1. Huson SM, Harper PS, Compston DA. Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales. Brain. 1988;111(Pt 6):1355–81.

    Article  PubMed  Google Scholar 

  2. Cawthon RM, Weiss R, Xu GF, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O’Connell P. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell. 1990;62(1):193–201.

    Article  CAS  PubMed  Google Scholar 

  3. Mulvihill JJ, Parry DM, Sherman JL, Pikus A, Kaiser-Kupfer MI, Eldridge R. NIH conference. Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis). An update. Ann Intern Med. 1990;113(1):39–52.

    Article  CAS  PubMed  Google Scholar 

  4. Thakkar SD, Feigen U, Mautner VF. Spinal tumours in neurofibromatosis type 1: an MRI study of frequency, multiplicity and variety. Neuroradiology. 1999;41(9):625–9.

    Article  CAS  PubMed  Google Scholar 

  5. Kluwe L, Tatagiba M, Funsterer C, Mautner VF. NF1 mutations and clinical spectrum in patients with spinal neurofibromas. J Med Genet. 2003;40(5):368–71.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic–pathologic correlation. Radiographics. 2002;22(4):911–34.

    Article  PubMed  Google Scholar 

  7. Bacci C, Sestini R, Ammannati F, Bianchini E, Palladino T, Carella M, Melchionda S, Zelante L, Papi L. Multiple spinal ganglioneuromas in a patient harboring a pathogenic NF1 mutation. Clin Genet. 2010;77(3):293–7.

    Article  CAS  PubMed  Google Scholar 

  8. Miyakoshi N, Hongo M, Kasukawa Y, Misawa A, Shimada Y. Bilateral and symmetric C1–C2 dumbbell ganglioneuromas associated with neurofibromatosis type 1 causing severe spinal cord compression. Spine J. 2010;10(4):e11–5.

    Article  PubMed  Google Scholar 

  9. Kyoshima K, Sakai K, Kanaji M, Oikawa S, Kobayashi S, Sato A, Nakayama J. Symmetric dumbbell ganglioneuromas of bilateral C2 and C3 roots with intradural extension associated with von Recklinghausen’s disease: case report. Surg Neurol. 2004;61(5):468–73 (discussion 73).

    Google Scholar 

  10. Shephard RH, Sutton D. Dumb-bell ganglioneuromata of the spine with a report of four cases. Br J Surg. 1958;45(192):305–17.

    Article  CAS  PubMed  Google Scholar 

  11. Japanese Orthopaedic Association scoring system for cervical myelopathy. J Jpn Orthop Assoc. 1994;68:134–47.

    Google Scholar 

  12. Ashkan K, Casey AT. Christmas tree sign. J Neurol Neurosurg Psychiatry. 1999;67(6):824.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Sinclair JE, Yang YH. Ganglioneuroma of the spine associated with von Recklinghausen’s disease. J Neurosurg. 1961;18:115–9.

    Google Scholar 

  14. Pang BC, Tchoyoson Lim CC, Tan KK. Giant spinal ganglioneuroma. J Clin Neurosci. 2005;12(8):967–72.

    Google Scholar 

  15. Carpenter WB, Kernohan JW. Retroperitoneal ganglioneuromas and neurofibromas. A clinicopathological study. Cancer. 1963;16:788–97.

    Article  CAS  PubMed  Google Scholar 

  16. Serebrin R, Robertson DM. Ganglioneuroma arising in the pituitary fossa: a twenty year follow-up. J Neurol Neurosurg Psychiatry. 1984;47(1):97–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Maggi G, Dorato P, Trischitta V, Varone A, Civetta F. Cervical dumbbell ganglioneuroma in an eighteen month old child. A case report. J Neurosurg Sci. 1995;39(4):257–60.

    CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shiro Imagama.

About this article

Cite this article

Ando, K., Imagama, S., Ito, Z. et al. Cervical myelopathy caused by bilateral C1–2 dumbbell ganglioneuromas and C2–3 and C3–4 neurofibromas associated with neurofibromatosis type 1. J Orthop Sci 19, 676–681 (2014). https://doi.org/10.1007/s00776-012-0315-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00776-012-0315-8

Keywords

Navigation