Skip to main content
Log in

Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor signaling axis in its pathogenesis

  • Case Report
  • Published:
Journal of Orthopaedic Science

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

References

  1. Hirakawa K, Hanakita J, Suwa H, Matsuoka N, Oda M, Muro H, Fukushima T. A post-traumatic ligamentum flavum progressive hematoma. Spine. 2000;25:1182–4.

    Article  PubMed  CAS  Google Scholar 

  2. Maezawa Y, Baba H, Uchida K, Kokubo Y, Kubota C, Noriki S. Ligamentum flavum hematoma in the thoracic spine. Clin Imaging. 2001;25:265–7.

    Article  PubMed  CAS  Google Scholar 

  3. Yayama T, Uchida K, Kobayashi S, Kokubo Y, Sato R, Nakajima H, Takamura T, Bangirana A, Itoh H, Baba H. Thoracic ossification of the human ligamentum flavum: histopathological and immunohistochemical findings around the ossified lesion. J Neurosurg Spine. 2007;7:184–93.

    Article  PubMed  Google Scholar 

  4. Zheng W, Seftor EA, Meininger CJ, Hendrix MJ, Tomanek RJ. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-beta. Am J Physiol Heart Circ Physiol. 2001;280:H909–17.

    PubMed  CAS  Google Scholar 

  5. van der Kraan PM, Blaney Davidson EN, Blom A, van den Berg WB. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage. 2009;17:1539–45.

    Article  PubMed  Google Scholar 

  6. Spuck S, Stellmacher F, Wiesmann M, Kranz R. A rare case of radicular complaint ligamentum flavum hematoma. Clin Orthop Relat Res. 2006;443:337–41.

    Article  PubMed  Google Scholar 

  7. Sudo H, Abumi K, Ito M, Kotani Y, Takahata M, Hojo Y, Sanda M, Minami A. Spinal cord compression by ligamentum flavum hematoma in the thoracic spine. Spine. 2009;34:E942–4.

    Article  PubMed  Google Scholar 

  8. Lee HW, Song JH, Chang IB, Choi HC. Spontaneous ligamentum flavum hematoma in the rigid thoracic spine: a case report and review of the literature. J Korean Neurosurg Soc. 2008;44:47–51.

    Article  PubMed  Google Scholar 

  9. Minamide A, Yoshida M, Tamaki T, Natsumi N. Ligamentum flavum hematoma in the lumbar spine. J Orthop Sci. 1999;4:376–9.

    Article  PubMed  CAS  Google Scholar 

  10. Kimoto S, Matsuzawa M, Matsubara S, Komatsu T, Uchimura N, Kawase T, Saito S. Cytokine secretion of periodontal ligament fibroblasts derived from human deciduous teeth: effect of mechanical stress on the secretion of transforming growth factor-beta 1 and macrophage colony stimulating factor. J Periodontal Res. 1999;34:235–43.

    Article  PubMed  CAS  Google Scholar 

  11. Nakatani T, Marui T, Hitora T, Doita M, Nishida K, Kurosaka M. Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1. J Orthop Res. 2002;20:1380–6.

    Article  PubMed  CAS  Google Scholar 

  12. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem. 1994;269:6271–4.

    PubMed  CAS  Google Scholar 

  13. Seko Y, Seko Y, Takahashi N, Shibuya M, Yazaki Y. Pulsatile stretch stimulates vascular endothelial growth factor (VEGF) secretion by cultured rat cardiac myocytes. Biochem Biophys Res Commun. 1999;25:462–5.

    Article  Google Scholar 

  14. Yayama T, Kobayashi S, Sato R, Uchida K, Kokubo Y, Nakajima H, Takaharu T, Mwaka E, Orwotho N, Baba H. Calcium pyrophosphate crystal deposition in the ligamentum flavum of degenerated lumbar spine: histopathological and immunohistological findings. Clin Rheumatol. 2008;27:597–604.

    Article  PubMed  Google Scholar 

  15. Matsumoto Y, Tanaka K, Hirata G, Hanada M, Matsuda S, Shuto T, Iwamoto Y. Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints. J Immunol. 2002;168:5824–31.

    PubMed  CAS  Google Scholar 

  16. Dorsay T, Helms C. MR imaging of epidural hematoma in the lumbar spine. Skeletal Radiol. 2002;31:677–85.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This paper was supported by a Grant-in-Aid for Scientific Research (C) (no. 23592192) from the Japan Society for the Promotion of Science, Tokyo, Japan.

Conflict of interest

There is no conflict of interest regarding the submitted article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yoshihiro Matsumoto.

About this article

Cite this article

Matsumoto, Y., Fujiwara, T., Imamura, R. et al. Hematoma of the ligamentum flavum in the thoracic spine: report of two cases and possible role of the transforming growth factor beta-vascular endothelial growth factor signaling axis in its pathogenesis. J Orthop Sci 18, 347–354 (2013). https://doi.org/10.1007/s00776-011-0150-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00776-011-0150-3

Keywords

Navigation