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Bioactive ceramic coating of cancellous screws improves the osseointegration in the cancellous bone

  • Original article
  • Published:
Journal of Orthopaedic Science

Abstract

Background

A number of methods for coating implants with bioactive ceramics have been reported to improve osseointegration in bone, but the effects of bioactive ceramic coatings on the osseointegration of cancellous screws are not known. Accordingly, biomechanical and histomorphometric analyses of the bone-screw interface of uncoated cancellous screws and cancellous screws coated with four different bioactive ceramics were performed.

Methods

After coating titanium alloy cancellous screws with calcium pyrophosphate (CPP), CaO–SiO2–B2O3 glass-ceramics (CSG), apatite-wollastonite 1:3 glass-ceramics (W3G), and CaO–SiO2–P2O5–B2O3 glass-ceramics (BGS-7) using an enameling method, the coated and the uncoated screws were inserted into the proximal tibia and distal femur metaphysis of seven male mongrel dogs. The torque values of the screws were measured at the time of insertion and at removal after 8 weeks. The bone-screw contact ratio was analyzed by histomorphometry.

Results

There was no significant difference in the insertion torque between the uncoated and coated screws. The torque values of the CPP and BGS-7 groups measured at removal after 8 weeks were significantly higher than those of the uncoated group. Moreover, the values of the CPP and BGS-7 groups were significantly higher than the insertion torques. The fraction of bone-screw interface measured from the undecalcified histological slide showed that the CPP, W3G, and BGS-7 groups had significantly higher torque values in the cortical bone area than the uncoated group, and the CPP and BGS-7 groups had significantly higher torque values in the cancellous bone area than the uncoated group.

Conclusions

In conclusion, a cancellous screw coated with CPP and BGS-7 ceramic bonds directly to cancellous bone to improve the bone-implant osseointegration. This may broaden the indications for cancellous screws by clarifying their contribution to improving osseointegration, even in the cancellous bone area.

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Acknowledgment

This study was supported by a Grant-in-Aid from the Korean Ministry of Knowledge Economy/KEIT (No. 10033623, Improvement of bone quality surrounding insertion hole for dental implant).

Conflict of interest

No benefits of any form have been received or will be received from any commercial party related directly or indirectly to the subject of this article.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Seoul National University, College of Medicine, SMG-SNU Boramae Medical Center, 425 Shindaebang 2-dong, Dongjak-gu, Seoul, 156-707, Korea

    Jae Hyup Lee

  2. Department of Orthopedic Surgery, Seoul National University, College of Medicine, Seoul National University Hospital, Seoul, 110-744, Korea

    Hwa Nam, Bong-Soon Chang & Choon-Ki Lee

  3. Research Center, Bioalpha, Sung-Nam, 462-120, Korea

    Hyun-Seung Ryu & Jun-Hyuk Seo

Authors
  1. Jae Hyup Lee
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  2. Hwa Nam
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  5. Bong-Soon Chang
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Correspondence to Jae Hyup Lee.

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Lee, J.H., Nam, H., Ryu, HS. et al. Bioactive ceramic coating of cancellous screws improves the osseointegration in the cancellous bone. J Orthop Sci 16, 291–297 (2011). https://doi.org/10.1007/s00776-011-0047-1

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  • DOI: https://doi.org/10.1007/s00776-011-0047-1

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