Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study
- 220 Downloads
The present study sought to identify dietary nutrients associated with the prevalence of radiographic knee osteoarthritis (OA) in the Japanese elderly of a population-based cohort of the Research on Osteoarthritis Against Disability (ROAD) study.
From the baseline survey of the ROAD study, 719 participants ≥60 years of age (270 men, 449 women) of a rural cohort were analyzed. Dietary nutrient intakes for the previous 1 month were assessed by a self-administered brief diet history questionnaire. The radiographic severity at both knees was determined by the Kellgren/Lawrence (KL) system.
The prevalence of knee OA of KL ≥2 was 70.8%. Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis. The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake. The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake.
The present cross-sectional study using a population-based cohort supports the hypothesis that low dietary vitamin K intake is a risk factor for knee OA. Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment.
KeywordsKnee Osteoarthritis Joint Space Narrowing Dietary Vitamin Dietary Survey Diet History Questionnaire
Unable to display preview. Download preview PDF.
- 1.Sharma L, Kapoor D. Epidemiology of osteoarthritis. In: Moskowitz RW, Altman RD, Hochberg MC, Buckwalter JA, Goldberg VM, editors. Osteoarthritis: diagnosis and medical/surgical management. 4th edn. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 3–26.Google Scholar
- 14.Kellgren JH, Lawrence JS, editors. the epidemiology of chronic rheumatism: atlas of standard radiographs of arthritis. Oxford: Blackwell Scientific; 1963.Google Scholar
- 29.Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part I. Critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage 2007;15:981–1000.CrossRefPubMedGoogle Scholar
- 30.Simon LS, Strand V. The pharmacologic treatment of osteoarthritis. In: Moskowitz RW, Altman RD, Hochberg MC, Buckwalter JA, Goldberg VM, editors. Osteoarthritis: diagnosis and medical/surgical management. 4th edn. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 267–286.Google Scholar