Journal of Orthopaedic Science

, Volume 14, Issue 6, pp 687–692 | Cite as

Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD study

  • Hiroyuki Oka
  • Toru Akune
  • Shigeyuki Muraki
  • Yoshio En-Yo
  • Munehito Yoshida
  • Akihiro Saika
  • Satoshi Sasaki
  • Kozo Nakamura
  • Hiroshi Kawaguchi
  • Noriko Yoshimura
Original Article



The present study sought to identify dietary nutrients associated with the prevalence of radiographic knee osteoarthritis (OA) in the Japanese elderly of a population-based cohort of the Research on Osteoarthritis Against Disability (ROAD) study.


From the baseline survey of the ROAD study, 719 participants ≥60 years of age (270 men, 449 women) of a rural cohort were analyzed. Dietary nutrient intakes for the previous 1 month were assessed by a self-administered brief diet history questionnaire. The radiographic severity at both knees was determined by the Kellgren/Lawrence (KL) system.


The prevalence of knee OA of KL ≥2 was 70.8%. Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis. The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake. The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake.


The present cross-sectional study using a population-based cohort supports the hypothesis that low dietary vitamin K intake is a risk factor for knee OA. Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment.


Knee Osteoarthritis Joint Space Narrowing Dietary Vitamin Dietary Survey Diet History Questionnaire 
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Copyright information

© The Japanese Orthopaedic Association 2009

Authors and Affiliations

  • Hiroyuki Oka
    • 1
  • Toru Akune
    • 2
  • Shigeyuki Muraki
    • 2
  • Yoshio En-Yo
    • 3
  • Munehito Yoshida
    • 3
  • Akihiro Saika
    • 4
  • Satoshi Sasaki
    • 5
  • Kozo Nakamura
    • 6
  • Hiroshi Kawaguchi
    • 6
  • Noriko Yoshimura
    • 1
  1. 1.Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of MedicineThe University of TokyoTokyoJapan
  3. 3.Department of Orthopaedic SurgeryWakayama Medical UniversityWakayamaJapan
  4. 4.Saika ClinicWakayamaJapan
  5. 5.Department of Social and Preventive Epidemiology, School of Public Health, Graduate School of MedicineThe University of TokyoTokyoJapan
  6. 6.Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of MedicineThe University of TokyoTokyoJapan

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