Skip to main content
SpringerLink
Log in

Regenerated soft tissue survival using repulsive force of magnetized devices: preliminary report

  • Original article
  • Published:
Journal of Orthopaedic Science

Abstract

Background

Large full-thickness cartilage defects in the weight-bearing area are difficult to treat. A new therapeutic strategy called the total joint regeneration (TJR) system is proposed for such large defects. The purpose of this study was to evaluate the effects of the magnet-type TJR device using a rabbit model.

Methods

The magnetized devices were implanted in full-thickness chondral defects on the patellofemoral joints of rabbits. The specimens and surrounding tissue were harvested 4 weeks after the surgery and observed macroscopically and histologically. The thickness of the regenerated soft tissue on the femur joint surface was measured and compared. The difference between the two groups (magnetized and nonmagnetized) was significant at P < 0.05.

Results

Some cartilaginous regeneration was seen in the repair tissue. However, about half of the experimental knees were omitted from the study because of some trouble, such as loosening of the device or patella fracture.

Conclusions

This study suggested that magnetized devices were useful for regenerating soft tissue by maintaining the joint space. Some hyaline cartilage-like tissue was regenerated partially on the magnetized devices. It was suggested that these devices might be useful for cartilage regeneration if the devices are improved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M Brittberg A Lindahl A Nilsson C Ohlsson O Isaksson L Peterson (1994) ArticleTitleTreatment of deep cartilage defects in the knee with autologous chondrocyte transplantation N Engl J Med 331 889–95 10.1056/NEJM199410063311401 Occurrence Handle10.1056/NEJM199410063311401 Occurrence Handle1:STN:280:DyaK2czlvFGlug%3D%3D Occurrence Handle8078550

    Article  CAS  PubMed  Google Scholar 

  2. M Ochi Y Uchio K Kawasaki S Wakitani J Iwasa (2002) ArticleTitleTransplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee J Bone Joint Surg Br 84 571–8 Occurrence Handle10.1302/0301-620X.84B4.11947 Occurrence Handle1:STN:280:DC%2BD38zgt1yksg%3D%3D Occurrence Handle12043781

    Article  CAS  PubMed  Google Scholar 

  3. L Hangody G Kish Z Karpati I Szerb I Udvarhelyi (1997) ArticleTitleArthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects: a preliminary report Knee Surg Sports Traumatol Arthrosc 5 262–7 10.1007/s001670050061 Occurrence Handle10.1007/s001670050061 Occurrence Handle1:STN:280:DyaK1c%2FptVCnsQ%3D%3D Occurrence Handle9430578

    Article  CAS  PubMed  Google Scholar 

  4. Y Matsusue T Kotake Y Nakagawa T Nakamura (2001) ArticleTitleArthroscopic osteochondral autograft transplantation for chondral lesion of the tibial plateau of the knee Arthroscopy 17 653–9 Occurrence Handle1:STN:280:DC%2BD38%2FitFCmuw%3D%3D Occurrence Handle11447556 Occurrence Handle10.1053/jars.2001.22400

    Article  CAS  PubMed  Google Scholar 

  5. DA Lee DL Bader (1997) ArticleTitleCompressive strain at physiological frequencies influence the metabolism of chondrocytes seeded in agarose J Orthop Res 15 181–8 Occurrence Handle10.1002/jor.1100150205 Occurrence Handle9167619

    Article  PubMed  Google Scholar 

  6. DA Lee T Noguchi MM Knight L O'Donnell G Bentley DL Bader (1998) ArticleTitleResponse of chondrocytes subpopulations cultured within unloaded and loaded agarose J Orthop Res 16 726–33 Occurrence Handle10.1002/jor.1100160615 Occurrence Handle1:STN:280:DyaK1M%2Fptlahtw%3D%3D Occurrence Handle9877398

    Article  CAS  PubMed  Google Scholar 

  7. MM Knight DA Lee DL Bader (1998) ArticleTitleThe influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose Biochim Biophys Acta 1405 67–77 Occurrence Handle10.1016/S0167-4889(98)00102-5 Occurrence Handle1:CAS:528:DyaK1cXmslOgsLs%3D Occurrence Handle9784610

    Article  CAS  PubMed  Google Scholar 

  8. S Mizuno T Ushida T Tateishi J Glowacki (1998) ArticleTitleEffects of physical stimulation on chondrogenesis in vitro Mat Sci Eng C6 301–6 Occurrence Handle1:CAS:528:DyaK1MXntVGlsw%3D%3D

    CAS  Google Scholar 

  9. T Murata T Ushida S Mizuno T Tateishi (1998) ArticleTitleProteoglycan synthesis by chondrocytes cultured under hydrostatic pressure and perfusion Mat Sci Eng C6 297–300 Occurrence Handle1:CAS:528:DyaK1MXntVGlsg%3D%3D

    CAS  Google Scholar 

  10. N Tomita H Aoki Y Harada K Ikeuchi S Wakitani K Hattori et al. (2002) Reconstruction of the knee joint using the total joint regeneration system Y Ikeda Y Umakoshi T Hotta (Eds) Tissue engineering for therapeutic use 6 Elsevier Science Amsterdam 41–9

    Google Scholar 

  11. S Wakitani K Imoto T Yamamoto M Saito N Murata M Yoneda (2002) ArticleTitleHuman autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees Osteoarthritis Cartilage 10 199–206 Occurrence Handle10.1053/joca.2001.0504 Occurrence Handle1:STN:280:DC%2BD387jsFegug%3D%3D Occurrence Handle11869080

    Article  CAS  PubMed  Google Scholar 

  12. K Kumagai T Saito T Koshino (2003) ArticleTitleArticular cartilage repair of rabbit chondral defect: promoted by creation of periarticular bony defect J Orthop Sci 8 700–6 10.1007/s00776-003-0696-9 Occurrence Handle10.1007/s00776-003-0696-9 Occurrence Handle14557937

    Article  PubMed  Google Scholar 

  13. RB Salter (1989) ArticleTitleThe biologic concept of continuous passive motion of synovial joints: the first 18 years of basic research and its clinical application Clin Orthop 242 12–25 Occurrence Handle2650945

    PubMed  Google Scholar 

  14. RB Salter (1994) ArticleTitleThe physiologic basis of continuous passive motion for articular cartilage healing and regeneration Hand Clin 10 211–9 Occurrence Handle1:STN:280:DyaK2czhsVyjuw%3D%3D Occurrence Handle8040199

    CAS  PubMed  Google Scholar 

  15. RB Salter (1996) ArticleTitleHistory of rest and motion and scientific basis for early continuous passive motion Hand Clin 12 1–11 Occurrence Handle1:STN:280:DyaK283jt12gsQ%3D%3D Occurrence Handle8655611

    CAS  PubMed  Google Scholar 

  16. Y Fujisawa K Masuhara S Shiomi (1979) ArticleTitleThe effect of high tibial osteotomy on osteoarthritis of the knee: an arthroscopic study of 54 knee joints Orthop Clin North Am 10 585–608 Occurrence Handle1:STN:280:DyaE1M3it1yhsw%3D%3D Occurrence Handle460834

    CAS  PubMed  Google Scholar 

  17. Y Harada N Tomita S Wakitani Y Mii M Oka S Tsutsumi (2002) ArticleTitleUse of controlled mechanical stimulation in vivo to induce cartilage layer formation on the surface of osteotomized bone Tissue Eng 8 969–78 10.1089/107632702320934065 Occurrence Handle10.1089/107632702320934065 Occurrence Handle12542942

    Article  PubMed  Google Scholar 

  18. F Shapiro S Koide MJ Glimcher (1993) ArticleTitleCell origin and differentiation in the repair of full-thickness defects of articular cartilage J Bone Joint Surg Am 75 532–53 Occurrence Handle1:STN:280:DyaK3s3jvFOmtg%3D%3D Occurrence Handle8478382

    CAS  PubMed  Google Scholar 

  19. J Nafziger L Devevey V Tricottet JJ Guillosson G Averlant M Arock (1997) ArticleTitleInvestigation of the effects of 50 Hz magnetic fields on purified human hematopoietic progenitors Life Sci 61 1935–46 10.1016/S0024-3205(97)00833-3 Occurrence Handle10.1016/S0024-3205(97)00833-3 Occurrence Handle1:CAS:528:DyaK2sXmslegurY%3D Occurrence Handle9364198

    Article  CAS  PubMed  Google Scholar 

  20. IB Schiffer WG Schreiber R Graf EM Schreiber D Jung DM Rose et al. (2003) ArticleTitleNo influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI Bioelectromagnetics 24 241–50 10.1002/bem.10097 Occurrence Handle10.1002/bem.10097 Occurrence Handle12696084

    Article  PubMed  Google Scholar 

  21. AT Barker R Jalinous IL Freeston (1985) ArticleTitleNoninvasive magnetic stimulation of human motor cortex Lancet 1 1106–7 Occurrence Handle10.1016/S0140-6736(85)92413-4 Occurrence Handle1:STN:280:DyaL2M3ht1Kjuw%3D%3D Occurrence Handle2860322

    Article  CAS  PubMed  Google Scholar 

  22. A Kitsugi O Okuno T Nakano H Hamanaka T Kuroda (1992) ArticleTitleThe corrosion behavior of Nd2Fe14B and SmCo5 magnets Dent Mater J 11 119–29 Occurrence Handle1:CAS:528:DyaK3sXkvVSisL8%3D Occurrence Handle1304968

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan

    Yasushi Seto & Yoshinori Takakura

  2. International Innovation Center, Kyoto University, Yoshida-Hon-machi, Sakyo-ku, Kyoto, 606-8501, Japan

    Naohide Tomita & Yasuji Harada

  3. Nakashima Medical Division, Nakashima Propeller Co., Okayama, Japan

    Hideyuki Sakoda

Authors
  1. Yasushi Seto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naohide Tomita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasuji Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hideyuki Sakoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshinori Takakura
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Seto, Y., Tomita, N., Harada, Y. et al. Regenerated soft tissue survival using repulsive force of magnetized devices: preliminary report. J Orthop Sci 11, 58–63 (2006). https://doi.org/10.1007/s00776-005-0978-5

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00776-005-0978-5

Keywords

Search

Navigation