Syntheses and structures of M(L)(X)BPh4 complexes {M=Co(II), Zn(II); L=cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane, X=OAc, NO3}: structural models of the active site of carbonic anhydrase

  • Leroy Cronin
  • Simon P. Foxon
  • Paul J. Lusby
  • Paul H. Walton
Original Article

Abstract

The metal coordination geometries in the structures of the zinc(II) and cobalt(II) complexes of the ligand cis-1,3,5-tris[3-(2-furyl)prop-2-enylideneamino]cyclohexane (fr-protach) and with the anions nitrate and acetate are structural models for the active site of carbonic anhydrase. The acetate structures show a striking structural correlation with the metal coordination environments in the known bicarbonate forms of the enzyme. Such structures provide a basis for understanding the marked effect of different metal substitution on the catalytic rate of the enzyme.

Keywords

Carbonic anhydrase Triaminocyclohexane Biomimicry Zinc Cobalt 

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Copyright information

© SBIC 2001

Authors and Affiliations

  • Leroy Cronin
  • Simon P. Foxon
  • Paul J. Lusby
  • Paul H. Walton

There are no affiliations available

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