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Synthesis and antibacterial activity of iron-hexacyanocobaltate nanoparticles

JBIC Journal of Biological Inorganic Chemistry volume 23, pages 385–398 (2018)Cite this article

Abstract

This paper deals with the synthesis and characterization of iron-hexacyanocobaltate (FeHCC) and its antibacterial properties. The nanoparticles were prepared by a facile co-precipitation technique. Crystal structure, particle morphology, and elemental composition were determined using X-ray Powder Diffraction, X-ray fluorescence spectroscopy, Transmission Electron Microscopy (TEM), and Infrared Spectroscopy (IR). The antibacterial activity of the FeHCC nanoparticles was tested against Escherichia coli and Staphylococcus aureus as models for Gram-negative and Gram-positive bacteria, respectively, by bacterial counting method and microscopic visualization (TEM, FEG-SEM, and fluorescence microscopy). The results showed that the FeHCC nanoparticles bind to the bacterial cells, inhibit bacterial growth in a dose- and time-dependent manner, inducing a loss of the membrane potential, the production of reactive oxygen species and the release of macromolecules (nucleic acids and proteins) in the extracellular environment. To the best of our knowledge, this is the first study reporting the antimicrobial effects of metal-hexacyanometallates suggesting practical uses of these materials in different areas, such as self-cleaning surfaces or food packaging.

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Acknowledgements

This work is part of the project “Development and Application of Innovative Materials and processes for the diagnosis and restoration of Cultural Heritage–DELIAS”–PON03PE_00214_2 (Programma Operativo Nazionale Ricerca e Competitività 2007–2013). TEM experimental data were provided by Polo Centro Grandi Apparecchiature—ATeN Center—Università di Palermo funded by P.O.R. Sicilia 2000–2006, Misura 3.15 Azione C Quota Regionale. FEG-SEM experimental data were provided by the ATeN-Center of University of Palermo, Laboratorio di preparazione di biomateriali.

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Authors and Affiliations

  1. Department of Industrial Chemistry “Toso Montanari”, University of Bologna, UOS Campus di Rimini, Via dei Mille 39, 47921, Rimini, Italy

    Michela Ciabocco & Mario Berrettoni

  2. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze bd.16 and 17, 90128, Palermo, Italy

    Patrizia Cancemi, Maria Luisa Saladino, Eugenio Caponetti & Rosa Alduina

  3. Polo CGA-ATeN-Center, University of Palermo, Via F. Marini 14, 90128, Palermo, Italy

    Maria Luisa Saladino & Eugenio Caponetti

Authors
  1. Michela Ciabocco
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  2. Patrizia Cancemi
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  3. Maria Luisa Saladino
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  4. Eugenio Caponetti
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  5. Rosa Alduina
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  6. Mario Berrettoni
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Corresponding author

Correspondence to Mario Berrettoni.

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Ciabocco, M., Cancemi, P., Saladino, M.L. et al. Synthesis and antibacterial activity of iron-hexacyanocobaltate nanoparticles. J Biol Inorg Chem 23, 385–398 (2018). https://doi.org/10.1007/s00775-018-1544-x

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  • DOI: https://doi.org/10.1007/s00775-018-1544-x

Keywords

  • Metal-hexacyanoferrates
  • Iron-hexacyanocobaltate
  • Antibacterial activity
  • Escherichia coli
  • Staphylococcus aureus