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Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions

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Abstract

Noncovalent weak interactions [hydrophobic interaction and hydrogen (H)-bond] play crucial roles in controlling the functions of biomolecules, and thus have been used to design artificial metalloproteins/metalloenzymes during the past few decades. In this review, we focus on the recent progresses in protein design by tuning the noncovalent interactions, including hydrophobic and H-bonding interactions. The topics include redesign and reuse of the heme pocket and other protein scaffolds, design of the heme protein interface, and de novo design of metalloproteins. The informations not only give insights into the metalloenzyme reaction mechanisms but also provide new reactions for future applications.

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Acknowledgements

The authors thank the supports by Grants-in-Aid from JSPS for Scientific Research Category B (No. JP26288080, S.H.) and Innovative Areas (No. JP16H00839, S.H.), the National Natural Science Foundation of China (No. 31370812, Y.-W.L.), and Hunan Provincial Natural Science Foundation (No. 2015JJ1012, Y.-W.L.).

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Authors and Affiliations

  1. Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, 630-0192, Japan

    Shun Hirota

  2. School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China

    Ying-Wu Lin

Authors
  1. Shun Hirota
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  2. Ying-Wu Lin
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Correspondence to Shun Hirota or Ying-Wu Lin.

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Hirota, S., Lin, YW. Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions. J Biol Inorg Chem 23, 7–25 (2018). https://doi.org/10.1007/s00775-017-1506-8

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  • DOI: https://doi.org/10.1007/s00775-017-1506-8

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