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Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent

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Abstract

Polyoxometalates (POMs) show promising biological activities, but the mechanism of potential therapeutic effects remains to be elucidated at a molecular level. As a step toward the elucidation of the mechanistic pathways governing the bioactivity of POMs, the interaction between Eu-containing decatungstate [EuW10O36]9− (EuW10) and histone H1 has been studied. Fluorescence/luminescence analysis showed the existence of a strong interaction between EuW10 and histone H1. This interaction has key effects both on the luminescence of EuW10 and on the structure of histone H1. A gradual and intense enhancement of EuW10 luminescence was observed upon addition of increasing concentrations of histone H1. Circular dichroism investigations indicated that the binding of EuW10 significantly alters the secondary structure of histone H1. The present work is meaningful in finding novel labeling agents for fluorescence/luminescence or solid-state bioimaging.

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Acknowledgements

This work was supported by the One Hundred Talent Program of the Chinese Academy of Science, National Natural Science Foundation of China (no. 20733006, 50720145202), the CNRS (UMR 8000), and Université Paris-Sud 11, France.

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Authors and Affiliations

  1. Key Laboratory of Green Process Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China

    Li Zheng & Guangjin Zhang

  2. Beijing National Laboratory for Molecular Science, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Li Zheng, Ying Ma & Jiannian Yao

  3. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, 100049, Beijing, China

    Zhanjun Gu

  4. Laboratoire de Chimie Physique, UMR 8000 CNRS, Université Paris-Sud 11, 91405, Orsay Cedex, France

    Bineta Keita & Louis Nadjo

  5. Graduated University of Chinese Academy of Sciences, Beijing, 100039, China

    Li Zheng

Authors
  1. Li Zheng
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  2. Zhanjun Gu
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  3. Ying Ma
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  4. Guangjin Zhang
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Corresponding authors

Correspondence to Guangjin Zhang, Jiannian Yao or Bineta Keita.

Additional information

We dedicate this paper to the memory of Dr. Constantin T. Craescu, who passed away last September.

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Zheng, L., Gu, Z., Ma, Y. et al. Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent. J Biol Inorg Chem 15, 1079–1085 (2010). https://doi.org/10.1007/s00775-010-0667-5

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  • DOI: https://doi.org/10.1007/s00775-010-0667-5

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