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Long-range charge transport through double-stranded DNA mediated by manganese or iron porphyrins

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Abstract

Guanine oxidation by electron transfer results in the formation of a guanine radical cation, which is at the origin of long-range charge transport through double-stranded DNA. It is possible to observe guanine lesions at a long distance from the oxidative reagent covalently bound to DNA owing to the migration of the positive hole in the DNA π-stacks. This phenomenon of long-range hole transport is classically studied in the literature with photosensitizers used as one-electron oxidants. It is shown in the present work that the process of long-range charge transport and the concomitant formation of guanine lesions at a long distance can be observed also in the case of two-electron oxidants. This is the signature of the formation of a transient guanine radical cation in the course of the two-electron abstraction process and consequently evidence of the separated one plus one electron abstraction steps. Long-range charge transport is likely to be a universal mechanism for any two-electron oxidant acting by electron abstraction provided that the second electron abstraction is slower than hole transfer.

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Acknowledgments

A NATO Science Fellowship to M.M. is gratefully acknowledged. The authors thank Bernard Meunier for fruitful discussion.

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  1. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077, Toulouse Cedex 4, France

    Magdalena Makarska & Geneviève Pratviel

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  1. Magdalena Makarska
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  2. Geneviève Pratviel
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Correspondence to Geneviève Pratviel.

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Makarska, M., Pratviel, G. Long-range charge transport through double-stranded DNA mediated by manganese or iron porphyrins. J Biol Inorg Chem 13, 973–979 (2008). https://doi.org/10.1007/s00775-008-0384-5

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  • DOI: https://doi.org/10.1007/s00775-008-0384-5

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